Literature DB >> 26942091

Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-Evidence to turn on the LIGHT.

Ajay V Maker1.   

Abstract

Targeted immunotherapy for solid gastrointestinal malignancies is challenging due to a lack of identified tumor antigens. Therefore, a strategy that supports and expands tumor infiltrating lymphocytes in the tumor microenvironment may allow these tumor-reactive T-cells to incite an antitumor response. Gene expression analysis of colon metastases has identified specific immunotherapeutic targets for this malignancy.

Entities:  

Keywords:  Colon cancer; LIGHT; Tnfsf14; gastrointestinal cancers; immunotherapy; metastasis; tumor infiltrating lymphocytes; tumor microenvironment

Year:  2015        PMID： 26942091      PMCID： PMC4760328          DOI： 10.1080/2162402X.2015.1069937

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Effector memory T cells, early metastasis, and survival in colorectal cancer.

Authors:  Franck Pagès; Anne Berger; Matthieu Camus; Fatima Sanchez-Cabo; Anne Costes; Robert Molidor; Bernhard Mlecnik; Amos Kirilovsky; Malin Nilsson; Diane Damotte; Tchao Meatchi; Patrick Bruneval; Paul-Henri Cugnenc; Zlatko Trajanoski; Wolf-Herman Fridman; Jérôme Galon
Journal:  N Engl J Med       Date:  2005-12-22       Impact factor: 91.245

2.  Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade.

Authors:  Ajay V Maker; Peter Attia; Steven A Rosenberg
Journal:  J Immunol       Date:  2005-12-01       Impact factor: 5.422

3.  Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.

Authors:  Dung T Le; Andrea Wang-Gillam; Vincent Picozzi; Tim F Greten; Todd Crocenzi; Gregory Springett; Michael Morse; Herbert Zeh; Deirdre Cohen; Robert L Fine; Beth Onners; Jennifer N Uram; Daniel A Laheru; Eric R Lutz; Sara Solt; Aimee Luck Murphy; Justin Skoble; Ed Lemmens; John Grous; Thomas Dubensky; Dirk G Brockstedt; Elizabeth M Jaffee
Journal:  J Clin Oncol       Date:  2015-01-12       Impact factor: 44.544

4.  Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study.

Authors:  Ajay V Maker; Giao Q Phan; Peter Attia; James C Yang; Richard M Sherry; Suzanne L Topalian; Udai S Kammula; Richard E Royal; Leah R Haworth; Catherine Levy; David Kleiner; Sharon A Mavroukakis; Michael Yellin; Steven A Rosenberg
Journal:  Ann Surg Oncol       Date:  2005-10-21       Impact factor: 5.344

5.  Regulatory T cell infiltration predicts outcome following resection of colorectal cancer liver metastases.

Authors:  Steven C Katz; Zubin M Bamboat; Ajay V Maker; Jinru Shia; Venu G Pillarisetty; Adam C Yopp; Cyrus V Hedvat; Mithat Gonen; William R Jarnagin; Yuman Fong; Michael I D'Angelica; Ronald P DeMatteo
Journal:  Ann Surg Oncol       Date:  2012-09-26       Impact factor: 5.344

6.  Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.

Authors:  Jérôme Galon; Anne Costes; Fatima Sanchez-Cabo; Amos Kirilovsky; Bernhard Mlecnik; Christine Lagorce-Pagès; Marie Tosolini; Matthieu Camus; Anne Berger; Philippe Wind; Franck Zinzindohoué; Patrick Bruneval; Paul-Henri Cugnenc; Zlatko Trajanoski; Wolf-Herman Fridman; Franck Pagès
Journal:  Science       Date:  2006-09-29       Impact factor: 47.728

7.  Genetic evidence that intratumoral T-cell proliferation and activation are associated with recurrence and survival in patients with resected colorectal liver metastases.

Authors:  Ajay V Maker; Hiromichi Ito; Qianxing Mo; Elliot Weisenberg; Li-Xuan Qin; Simon Turcotte; Shishir Maithel; Jinru Shia; Leslie Blumgart; Yuman Fong; William R Jarnagin; Ronald P DeMatteo; Michael I D'Angelica
Journal:  Cancer Immunol Res       Date:  2015-01-19       Impact factor: 11.151

8.  Cancer immunotherapy: moving beyond current vaccines.

Authors:  Steven A Rosenberg; James C Yang; Nicholas P Restifo
Journal:  Nat Med       Date:  2004-09       Impact factor: 53.440

9.  Priming of naive T cells inside tumors leads to eradication of established tumors.

Authors:  Ping Yu; Youjin Lee; Wenhua Liu; Robert K Chin; Jing Wang; Yang Wang; Andrea Schietinger; Mary Philip; Hans Schreiber; Yang-Xin Fu
Journal:  Nat Immunol       Date:  2004-01-04       Impact factor: 25.606

10.  Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.

Authors:  Jian Zhong Qin; Vivek Upadhyay; Bellur Prabhakar; Ajay V Maker
Journal:  J Transl Med       Date:  2013-03-20       Impact factor: 5.531
  10 in total
  7 in total

Review 1.  Trial watch: Immune checkpoint blockers for cancer therapy.

Authors:  Claire Vanpouille-Box; Claire Lhuillier; Lucillia Bezu; Fernando Aranda; Takahiro Yamazaki; Oliver Kepp; Jitka Fucikova; Radek Spisek; Sandra Demaria; Silvia C Formenti; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2017-08-31       Impact factor: 8.110

2.  LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.

Authors:  Guilin Qiao; Jianzhong Qin; Nicholas Kunda; Jed F Calata; Dolores L Mahmud; Peter Gann; Yang-Xin Fu; Steven A Rosenberg; Bellur S Prabhakar; Ajay V Maker
Journal:  Cancer Res       Date:  2017-03-01       Impact factor: 12.701

3.  Combination Immunotherapy With LIGHT and Interleukin-2 Increases CD8 Central Memory T-Cells In Vivo.

Authors:  Manuel F Fernandez; Guilin Qiao; Kiara Tulla; Bellur S Prabhakar; Ajay V Maker
Journal:  J Surg Res       Date:  2021-02-22       Impact factor: 2.417

Review 4.  Gene-expression profiling to predict responsiveness to immunotherapy.

Authors:  N B Jamieson; A V Maker
Journal:  Cancer Gene Ther       Date:  2016-11-11       Impact factor: 5.987

5.  Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death.

Authors:  Jianzhong Qin; Nicholas Kunda; Guilin Qiao; Jed F Calata; Krunal Pardiwala; Bellur S Prabhakar; Ajay V Maker
Journal:  Cell Death Dis       Date:  2017-02-02       Impact factor: 8.469

6.  LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer.

Authors:  Guilin Qiao; Lyonell B Kone; Evan H Phillips; Steve Seung-Young Lee; Grace E Brown; Salman R Khetani; Archana Thakur; Lawrence G Lum; Bellur S Prabhakar; Ajay V Maker
Journal:  Oncogene       Date:  2022-02-17       Impact factor: 8.756

7.  Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice.

Authors:  Shiyun Dai; Yun Lv; Weidong Xu; Yuefeng Yang; Chao Liu; Xiwen Dong; Huan Zhang; Bellur S Prabhakar; Ajay V Maker; Prem Seth; Hua Wang
Journal:  Cancer Gene Ther       Date:  2020-04-20       Impact factor: 5.987
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.