Literature DB >> 26942089

Targeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma?

Florie Bertrand1, Julia Rochotte2, Céline Colacios2, Anne Montfort3, Nathalie Andrieu-Abadie1, Thierry Levade2, Hervé Benoist2, Bruno Ségui2.   

Abstract

Tumor Necrosis Factor α (TNF) is a pleiotropic cytokine exhibiting a dual activity in oncoimmunology, either acting as a cytotoxic effector produced by leukocytes or behaving as an immunosuppressive molecule. We have just discovered that TNF signaling impairs the accumulation of tumor-infiltrating CD8+ T lymphocytes in experimental melanoma.

Entities:  

Keywords:  Apoptosis; T lymphocytes; TNF; high endothelial venules; melanoma; tumor-infiltrating CD8+ lymphocytes

Year:  2015        PMID： 26942089      PMCID： PMC4760276          DOI： 10.1080/2162402X.2015.1068495

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Blocking Tumor Necrosis Factor α Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma.

Authors:  Florie Bertrand; Julia Rochotte; Céline Colacios; Anne Montfort; Anne-Françoise Tilkin-Mariamé; Christian Touriol; Philippe Rochaix; Isabelle Lajoie-Mazenc; Nathalie Andrieu-Abadie; Thierry Levade; Hervé Benoist; Bruno Ségui
Journal:  Cancer Res       Date:  2015-05-14       Impact factor: 12.701

2.  Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation.

Authors:  Jennifer Landsberg; Judith Kohlmeyer; Marcel Renn; Tobias Bald; Meri Rogava; Mira Cron; Martina Fatho; Volker Lennerz; Thomas Wölfel; Michael Hölzel; Thomas Tüting
Journal:  Nature       Date:  2012-10-10       Impact factor: 49.962

3.  Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy.

Authors:  Simon Turcotte; Alena Gros; Katherine Hogan; Eric Tran; Christian S Hinrichs; John R Wunderlich; Mark E Dudley; Steven A Rosenberg
Journal:  J Immunol       Date:  2013-07-31       Impact factor: 5.422

4.  BRAF(V600) inhibitor GSK2118436 targeted inhibition of mutant BRAF in cancer patients does not impair overall immune competency.

Authors:  David S Hong; Luis Vence; Gerald Falchook; Laszlo G Radvanyi; Chengwen Liu; Vicki Goodman; Jeffery J Legos; Sam Blackman; Antonio Scarmadio; Razelle Kurzrock; Gregory Lizee; Patrick Hwu
Journal:  Clin Cancer Res       Date:  2012-02-21       Impact factor: 12.531

5.  Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

Authors:  Xin Chen; Monika Bäumel; Daniela N Männel; O M Zack Howard; Joost J Oppenheim
Journal:  J Immunol       Date:  2007-07-01       Impact factor: 5.422

6.  TNF signaling drives myeloid-derived suppressor cell accumulation.

Authors:  Xueqiang Zhao; Lijie Rong; Xiaopu Zhao; Xiao Li; Xiaoman Liu; Jingjing Deng; Hao Wu; Xia Xu; Ulrike Erben; Peihua Wu; Uta Syrbe; Joachim Sieper; Zhihai Qin
Journal:  J Clin Invest       Date:  2012-10-15       Impact factor: 14.808

7.  A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer.

Authors:  E R Brown; K A Charles; S A Hoare; R L Rye; D I Jodrell; R E Aird; R Vora; U Prabhakar; M Nakada; R E Corringham; M DeWitte; C Sturgeon; D Propper; F R Balkwill; J F Smyth
Journal:  Ann Oncol       Date:  2008-03-05       Impact factor: 32.976

8.  Induction of apoptosis in mature T cells by tumour necrosis factor.

Authors:  L Zheng; G Fisher; R E Miller; J Peschon; D H Lynch; M J Lenardo
Journal:  Nature       Date:  1995-09-28       Impact factor: 49.962

9.  Tumor high endothelial venules (HEVs) predict lymphocyte infiltration and favorable prognosis in breast cancer.

Authors:  Ludovic Martinet; Ignacio Garrido; Jean-Philippe Girard
Journal:  Oncoimmunology       Date:  2012-08-01       Impact factor: 8.110

10.  High endothelial venules (HEVs) in human melanoma lesions: Major gateways for tumor-infiltrating lymphocytes.

Authors:  Ludovic Martinet; Sophie Le Guellec; Thomas Filleron; Laurence Lamant; Nicolas Meyer; Philippe Rochaix; Ignacio Garrido; Jean-Philippe Girard
Journal:  Oncoimmunology       Date:  2012-09-01       Impact factor: 8.110
  10 in total
  7 in total

1.  TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis.

Authors:  Yi Wen; Nathan P Rudemiller; Jiandong Zhang; Taylor Robinette; Xiaohan Lu; Jiafa Ren; Jamie R Privratsky; Sergei A Nedospasov; Steven D Crowley
Journal:  Am J Physiol Renal Physiol       Date:  2019-11-18

2.  TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma.

Authors:  Florie Bertrand; Anne Montfort; Elie Marcheteau; Caroline Imbert; Julia Gilhodes; Thomas Filleron; Philippe Rochaix; Nathalie Andrieu-Abadie; Thierry Levade; Nicolas Meyer; Céline Colacios; Bruno Ségui
Journal:  Nat Commun       Date:  2017-12-22       Impact factor: 14.919

3.  CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma.

Authors:  Chun Xu; Xian Lu; Wei Liu; Anxian Chen; Gang Meng; Hailin Zhang; Binghua Li; Yonghui Zhang; Junhua Wu; Jiwu Wei
Journal:  J Transl Med       Date:  2018-05-21       Impact factor: 5.531

4.  Effects of the IL6 -174G>C promoter polymorphism and IL-6 serum levels on the progression of cutaneous malignant melanoma.

Authors:  Tatyana Vlaykova; Mateuzh Kurzawski; Tanya Tacheva; Dimo Dimov; Asen Anastasov; Denitsa Vlaykova; Ani Miteva; Niamh O'donoghue; Marek Drozdzik
Journal:  Oncol Lett       Date:  2020-06-16       Impact factor: 2.967

5.  CD8+ tumor-infiltrating lymphocytes as a novel prognostic biomarker in lung sarcomatoid carcinoma, a rare subtype of lung cancer.

Authors:  Jiewei Chen; Qingmei He; Jun Liu; Yongbo Xiao; Canhua Xiao; Keming Chen; Dan Xie; Xinke Zhang
Journal:  Cancer Manag Res       Date:  2018-09-13       Impact factor: 3.989

6.  Investigating Macrophages Plasticity Following Tumour-Immune Interactions During Oncolytic Therapies.

Authors:  R Eftimie; G Eftimie
Journal:  Acta Biotheor       Date:  2019-08-13       Impact factor: 1.774

7.  Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling.

Authors:  Ruiqi Xu; Mengnan Zeng; Yuanyuan Wu; Shengchao Wang; Beibei Zhang; Jingke Zhang; Yuxuan Kan; Benke Li; Bing Cao; Xiaoke Zheng; Weisheng Feng
Journal:  Onco Targets Ther       Date:  2021-05-28       Impact factor: 4.147
  7 in total

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