Literature DB >> 26942081

The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity.

V A Alamino1, M M Montesinos1, G A Rabinovich2, C G Pellizas1.   

Abstract

Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy.

Entities:  

Keywords:  Cancer vaccination; dendritic cell; immunotherapy; thyroid hormone; triiodothyronine

Year:  2015        PMID： 26942081      PMCID： PMC4760281          DOI： 10.1080/2162402X.2015.1064579

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression.

Authors:  F Sallusto; A Lanzavecchia
Journal:  Immunol Rev       Date:  2000-10       Impact factor: 12.988

Review 2.  Thyroid hormone receptors and cancer.

Authors:  Won Gu Kim; Sheue-yann Cheng
Journal:  Biochim Biophys Acta       Date:  2012-04-06

3.  An essential role for Akt1 in dendritic cell function and tumor immunotherapy.

Authors:  Dongsu Park; Natalia Lapteva; Mamatha Seethammagari; Kevin M Slawin; David M Spencer
Journal:  Nat Biotechnol       Date:  2006-12-03       Impact factor: 54.908

Review 4.  Neuroendocrine factors alter host defense by modulating immune function.

Authors:  Cherie L Butts; Esther M Sternberg
Journal:  Cell Immunol       Date:  2008-03-07       Impact factor: 4.868

5.  Dexamethasone counteracts the immunostimulatory effects of triiodothyronine (T3) on dendritic cells.

Authors:  María M Montesinos; Vanina A Alamino; Iván D Mascanfroni; Sebastián Susperreguy; Nicolás Gigena; Ana M Masini-Repiso; Gabriel A Rabinovich; Claudia G Pellizas
Journal:  Steroids       Date:  2011-10-25       Impact factor: 2.668

Review 6.  Cancer immunotherapy via dendritic cells.

Authors:  Karolina Palucka; Jacques Banchereau
Journal:  Nat Rev Cancer       Date:  2012-03-22       Impact factor: 60.716

Review 7.  Thyroid hormones as modulators of immune activities at the cellular level.

Authors:  Paolo De Vito; Sandra Incerpi; Jens Z Pedersen; Paolo Luly; Faith B Davis; Paul J Davis
Journal:  Thyroid       Date:  2011-07-11       Impact factor: 6.568

8.  Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β.

Authors:  Vanina A Alamino; Iván D Mascanfroni; María M Montesinos; Nicolás Gigena; Ana C Donadio; Ada G Blidner; Sonia I Milotich; Sheue-Yann Cheng; Ana M Masini-Repiso; Gabriel A Rabinovich; Claudia G Pellizas
Journal:  Cancer Res       Date:  2015-02-11       Impact factor: 12.701

9.  Control of dendritic cell maturation and function by triiodothyronine.

Authors:  Ivan Mascanfroni; María del Mar Montesinos; Sebastián Susperreguy; Laura Cervi; Juan M Ilarregui; Vanesa D Ramseyer; Ana M Masini-Repiso; Héctor M Targovnik; Gabriel A Rabinovich; Claudia G Pellizas
Journal:  FASEB J       Date:  2007-11-08       Impact factor: 5.191

10.  Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling.

Authors:  Iván D Mascanfroni; María del Mar Montesinos; Vanina A Alamino; Sebastián Susperreguy; Juan P Nicola; Juan M Ilarregui; Ana M Masini-Repiso; Gabriel A Rabinovich; Claudia G Pellizas
Journal:  J Biol Chem       Date:  2009-12-17       Impact factor: 5.157
  10 in total
  5 in total

1.  Immunotherapy in anaplastic thyroid cancer.

Authors:  Maoguang Ma; Bo Lin; Mingdian Wang; Xiaoli Liang; Lei Su; Okenwa Okose; Weiming Lv; Jie Li
Journal:  Am J Transl Res       Date:  2020-03-15       Impact factor: 4.060

2.  A Role for Iodide and Thyroglobulin in Modulating the Function of Human Immune Cells.

Authors:  Mahmood Y Bilal; Svetlana Dambaeva; Joanne Kwak-Kim; Alice Gilman-Sachs; Kenneth D Beaman
Journal:  Front Immunol       Date:  2017-11-15       Impact factor: 7.561

3.  The Value of Decreased Thyroid Hormone for Predicting Mortality in Adult Septic Patients: A Systematic Review and Meta-Analysis.

Authors:  Jae Guk Kim; Hyungoo Shin; Wonhee Kim; Tae Ho Lim; Bohyoung Jang; Youngsuk Cho; Kyu-Sun Choi; Chiwon Ahn; Juncheol Lee; Min Kyun Na
Journal:  Sci Rep       Date:  2018-09-20       Impact factor: 4.379

Review 4.  Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors.

Authors:  Xavier Thuru; Romain Magnez; Hassiba El-Bouazzati; Gérard Vergoten; Bruno Quesnel; Christian Bailly
Journal:  Cancers (Basel)       Date:  2022-07-11       Impact factor: 6.575

Review 5.  Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy.

Authors:  Athanasios I Lourbopoulos; Iordanis S Mourouzis; Athanasios G Trikas; Ioulia K Tseti; Constantinos I Pantos
Journal:  J Clin Med       Date:  2021-12-14       Impact factor: 4.241
  5 in total

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