| Literature DB >> 26941864 |
Axel Van Der Gucht1, Mehdi Aoun-Sebaiti2, Paul Kauv3, Eric Guedj4, Jessie Aouizerate5, Antoine Verger6, Romain K Gherardi5, Anne-Catherine Bachoud-Levi7, François-Jérôme Authier5, Emmanuel Itti1.
Abstract
Brain Positron Emission Tomography/Computed Tomography with (18)F-fluorodeoxyglucose (FDG PET/CT) was performed in a 44-year-old woman with marked cognitive impairment, diffuse myalgias, sensory, memory and visual disorders, and chronic fatigue, presenting with histopathological features of macrophagic myofasciitis (MMF) at deltoid muscle biopsy. Cerebromedullary Magnetic Resonance Imaging (MRI), electromyography, ophthalmic examination, and cerebrospinal fluid analysis were normal. Visual analysis of FDG PET/CT images showed an atypical pattern of hypometabolism, involving symmetrically the occipital cortex, temporal lobes, and limbic system (including in particular amygdalo-hippocampal complexes), and the cerebellum. Posterior cingulate cortex and parietal areas were preserved. This pattern was confirmed by a voxel-based procedure using Statistical Parametric Mapping (SPM12) that compared a patient's images to normal reference samples from six healthy subjects with adjustment to age obtained using the same PET/CT camera. These results provide a glucose metabolism substrate for cognitive complaints in patients with long-lasting aluminium hydroxide-induced MMF.Entities:
Keywords: 18F-FDG; Aluminum hydroxide; Brain imaging; Macrophagic myofasciitis
Year: 2015 PMID： 26941864 PMCID： PMC4762870 DOI： 10.1007/s13139-015-0371-z
Source DB: PubMed Journal: Nucl Med Mol Imaging ISSN： 1869-3474