Eunkyung Park1, Yu Mi Hwang2, Min Kyung Chu3, Ki-Young Jung4. 1. Department of Nuclear Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea ; PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USA. 2. Center for Research Information, Korea University, Seoul, Republic of Korea. 3. Department of Neurology, Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea. 4. Department of Neurology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799 Republic of Korea.
Abstract
PURPOSE: Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([(18)F]FP-CIT) positron emission tomography (PET). METHODS: Brain [(18)F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BP ND) of [(18)F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters. RESULTS: BP ND at the brainstem was significantly higher in adult migraineurs (n = 6, 1.15 ± 0.17) than healthy subjects (0.95 ± 0.14) (p = 0.04). Healthy subjects demonstrated negative correlation between brainstem BP ND and age (r = -0.64, p = 0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP ND (r = 0.66, p = 0.02), when age and duration of illness were corrected. CONCLUSIONS: Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [(18)F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.
PURPOSE: Recent studies have proposed central serotonergic dysfunction as a major pathophysiology of migraine. We investigated serotonin transporter (SERT) availability in migraineurs using F-18-N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ([(18)F]FP-CIT) positron emission tomography (PET). METHODS: Brain [(18)F]FP-CIT PET images were obtained in eight women with migraine during headache free phase and 12 healthy adult women, 120 min after injection of 185 MBq. Non-displaceable binding potential (BP ND) of [(18)F]FP-CIT, which is an estimate of SERT availability, was calculated at the brainstem and compared with clinical parameters. RESULTS: BP ND at the brainstem was significantly higher in adult migraineurs (n = 6, 1.15 ± 0.17) than healthy subjects (0.95 ± 0.14) (p = 0.04). Healthy subjects demonstrated negative correlation between brainstem BP ND and age (r = -0.64, p = 0.02), whereas this age-related decline pattern was not found in the migraineurs. Severity of migraine attack was significantly correlated with brainstem BP ND (r = 0.66, p = 0.02), when age and duration of illness were corrected. CONCLUSIONS: Increased SERT availability in the brainstem of adult migraineurs indicates low serotonin neurotransmission during headache-free phase. Patients who experience more painful headaches have lower serotonin neurotransmission. [(18)F]FP-CIT PET is a useful in vivo imaging technique for evaluating brainstem SERT availability in migraineurs.
Authors: W Pirker; S Asenbaum; M Hauk; S Kandlhofer; J Tauscher; M Willeit; A Neumeister; N Praschak-Rieder; P Angelberger; T Brücke Journal: J Nucl Med Date: 2000-01 Impact factor: 10.057
Authors: Walter Koch; Marcus Unterrainer; Guoming Xiong; Peter Bartenstein; Markus Diemling; Andrea Varrone; John C Dickson; Livia Tossici-Bolt; Terez Sera; Susanne Asenbaum; Jan Booij; Ozlem L Kapucu; Andreas Kluge; Morten Ziebell; Jacques Darcourt; Flavio Nobili; Marco Pagani; Swen Hesse; Thierry Vander Borght; Koen Van Laere; Klaus Tatsch; Christian la Fougère Journal: Eur J Nucl Med Mol Imaging Date: 2014-05-08 Impact factor: 9.236
Authors: A Modabbernia; E Velthorst; C Gennings; L De Haan; C Austin; A Sutterland; J Mollon; S Frangou; R Wright; M Arora; A Reichenberg Journal: Eur Psychiatry Date: 2016-06-14 Impact factor: 5.361
Authors: Christopher T Smith; M Danica San Juan; Linh C Dang; Daniel T Katz; Scott F Perkins; Leah L Burgess; Ronald L Cowan; H Charles Manning; Michael L Nickels; Daniel O Claassen; Gregory R Samanez-Larkin; David H Zald Journal: Transl Psychiatry Date: 2018-12-07 Impact factor: 6.222