Literature DB >> 26941103

RIT2 Polymorphisms: Is There a Differential Association?

Babak Emamalizadeh1, Javad Jamshidi2, Abolfazl Movafagh1, Mina Ohadi3, Mahmoud Shekari Khaniani4,5, Somayyeh Kazeminasab6, Akbar Biglarian7, Shaghayegh Taghavi1, Marzieh Motallebi1, Atena Fazeli1, Azadeh Ahmadifard1, Gholam-Ali Shahidi8, Peyman Petramfar9, Neda Shahmohammadibeni10, Tahereh Dadkhah10, Ehteram Khademi10, Abbas Tafakhori11, Ali Khaligh12, Tannaz Safaralizadeh1, Ali Kowsari13, Arash Mirabzadeh14, Amir Ehtesham Shafiei Zarneh1, Mehdi Khorrami15, Parasto Shokraeian16, Mohammad Javad Soltani Banavandi17, Behnam Safarpour Lima18, Monavvar Andarva1, Elham Alehabib1, Minoo Atakhorrami1, Hossein Darvish19.   

Abstract

Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson's disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders.

Entities:  

Keywords:  Autism; Bipolar disorder; Essential tremor; Neurological disorders; Parkinson’s disease; Polymorphism; RIT2; Schizophrenia

Mesh：

Substances：

Year:  2016        PMID： 26941103     DOI： 10.1007/s12035-016-9815-4

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  50 in total

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3.  RIT2 rs12456492 polymorphism and the risk of Parkinson's disease: A meta-analysis.

Authors:  Xiaona Zhang; Mengyue Niu; Hong Li; Anmu Xie
Journal:  Neurosci Lett       Date:  2015-07-15       Impact factor: 3.046

4.  Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression.

Authors:  G Novak; P Seeman; T Tallerico
Journal:  Synapse       Date:  2006-01       Impact factor: 2.562

5.  The coincidence of schizophrenia and Parkinsonism: some neurochemical implications.

Authors:  T J Crow; E C Johnstone; H A McClelleand
Journal:  Psychol Med       Date:  1976-05       Impact factor: 7.723

Review 6.  Neurological considerations: autism and Parkinson's disease.

Authors:  Eric Hollander; A Ting Wang; Ashley Braun; Laura Marsh
Journal:  Psychiatry Res       Date:  2009-10-07       Impact factor: 3.222

Review 7.  Understanding neurological disease mechanisms in the era of epigenetics.

Authors:  Irfan A Qureshi; Mark F Mehler
Journal:  JAMA Neurol       Date:  2013-06       Impact factor: 18.302

8.  Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

Authors:  Nathan Pankratz; Gary W Beecham; Anita L DeStefano; Ted M Dawson; Kimberly F Doheny; Stewart A Factor; Taye H Hamza; Albert Y Hung; Bradley T Hyman; Adrian J Ivinson; Dmitri Krainc; Jeanne C Latourelle; Lorraine N Clark; Karen Marder; Eden R Martin; Richard Mayeux; Owen A Ross; Clemens R Scherzer; David K Simon; Caroline Tanner; Jeffery M Vance; Zbigniew K Wszolek; Cyrus P Zabetian; Richard H Myers; Haydeh Payami; William K Scott; Tatiana Foroud
Journal:  Ann Neurol       Date:  2012-03       Impact factor: 10.422

9.  Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

Authors:  Mike A Nalls; Nathan Pankratz; Christina M Lill; Chuong B Do; Dena G Hernandez; Mohamad Saad; Anita L DeStefano; Eleanna Kara; Jose Bras; Manu Sharma; Claudia Schulte; Margaux F Keller; Sampath Arepalli; Christopher Letson; Connor Edsall; Hreinn Stefansson; Xinmin Liu; Hannah Pliner; Joseph H Lee; Rong Cheng; M Arfan Ikram; John P A Ioannidis; Georgios M Hadjigeorgiou; Joshua C Bis; Maria Martinez; Joel S Perlmutter; Alison Goate; Karen Marder; Brian Fiske; Margaret Sutherland; Georgia Xiromerisiou; Richard H Myers; Lorraine N Clark; Kari Stefansson; John A Hardy; Peter Heutink; Honglei Chen; Nicholas W Wood; Henry Houlden; Haydeh Payami; Alexis Brice; William K Scott; Thomas Gasser; Lars Bertram; Nicholas Eriksson; Tatiana Foroud; Andrew B Singleton
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2.  The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?

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5.  Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.

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