Literature DB >> 26940609

New technologies in drug metabolism and toxicity screening: organ-to-organ interaction.

Abhinav Bhushan1, Nicole J Martucci2, O Berk Usta3, Martin L Yarmush3,4.   

Abstract

Entities:  

Keywords:  Drug metabolism; drug toxicity; humanized mice; induced pluripotent cells; microphysiological; organs on chips; systems

Mesh：

Substances：

Year:  2016        PMID： 26940609      PMCID： PMC4927438          DOI： 10.1517/17425255.2016.1162292

Source DB:  PubMed          Journal:  Expert Opin Drug Metab Toxicol        ISSN： 1742-5255            Impact factor:   4.481


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2.  A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity.

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3.  Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity.

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4.  Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.

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Journal:  Carcinogenesis       Date:  2010-11-15       Impact factor: 4.944

Review 5.  Organs-on-chips at the frontiers of drug discovery.

Authors:  Eric W Esch; Anthony Bahinski; Dongeun Huh
Journal:  Nat Rev Drug Discov       Date:  2015-03-20       Impact factor: 84.694

Review 6.  Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.

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7.  Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.

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Journal:  Toxicol Sci       Date:  2015-02-24       Impact factor: 4.849

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Authors:  Eva-Maria Materne; Anja Patricia Ramme; Ana Paula Terrasso; Margarida Serra; Paula Marques Alves; Catarina Brito; Dmitry A Sakharov; Alexander G Tonevitsky; Roland Lauster; Uwe Marx
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Review 9.  A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.

Authors:  Nico Scheer; Ian D Wilson
Journal:  Drug Discov Today       Date:  2015-09-07       Impact factor: 7.851

10.  Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

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1.  Drug absorption related nephrotoxicity assessment on an intestine-kidney chip.

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2.  Robotic fluidic coupling and interrogation of multiple vascularized organ chips.

Authors:  Richard Novak; Debarun Das; Anna Herland; Ben M Maoz; Mahadevabharath R Somayaji; Rachelle Prantil-Baun; Miles Ingram; Susan Marquez; Aaron Delahanty; Sauveur S F Jeanty; Morgan Burt; Elizabeth Calamari; Angeliki Chalkiadaki; Alexander Cho; Youngjae Choe; David Benson Chou; Michael Cronce; Stephanie Dauth; Toni Divic; Jose Fernandez-Alcon; Thomas Ferrante; John Ferrier; Edward A FitzGerald; Rachel Fleming; Sasan Jalili-Firoozinezhad; Thomas Grevesse; Josue A Goss; Tiama Hamkins-Indik; Olivier Henry; Chris Hinojosa; Tessa Huffstater; Kyung-Jin Jang; Ville Kujala; Lian Leng; Robert Mannix; Yuka Milton; Janna Nawroth; Bret A Nestor; Carlos F Ng; Blakely O'Connor; Tae-Eun Park; Henry Sanchez; Josiah Sliz; Alexandra Sontheimer-Phelps; Ben Swenor; Guy Thompson; George J Touloumes; Zachary Tranchemontagne; Norman Wen; Moran Yadid; Anthony Bahinski; Geraldine A Hamilton; Daniel Levner; Oren Levy; Andrzej Przekwas; Kevin K Parker; Donald E Ingber
Journal:  Nat Biomed Eng       Date:  2020-01-27       Impact factor: 25.671

3.  Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.

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Journal:  Front Pharmacol       Date:  2021-05-07       Impact factor: 5.810
  3 in total

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