Literature DB >> 269406

Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning.

R L Margolis, L Wilson.   

Abstract

Colchicine blocks microtubule polymerization by an unusual substoichiometric poisoning mechanism. We have investigated the mechanism by which this poisoning occurs with several experimental approaches, and have found that colchicine acts by addition to microtubule ends as a colchicine-tubulin complex.

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Year:  1977        PMID： 269406      PMCID： PMC431611          DOI： 10.1073/pnas.74.8.3466

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Biochemical studies on the in vitro assembly and disassembly of microtubules.

Authors:  F Gaskin; C R Cantor; M L Shelanski
Journal:  Ann N Y Acad Sci       Date:  1975-06-30       Impact factor: 5.691

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 3.  Microtuble assembly: some possible regulatory mechanisms.

Authors:  J B Olmsted; J M Marcum; K A Johnson; C Allen; G G Borisy
Journal:  J Supramol Struct       Date:  1974

4.  Directionality of brain microtubule assembly in vitro.

Authors:  W L Dentler; S Granett; G B Witman; J L Rosenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

5.  Characterization of microtubule assembly in porcine brain extracts by viscometry.

Authors:  J B Olmsted; G G Borisy
Journal:  Biochemistry       Date:  1973-10-09       Impact factor: 3.162

6.  Microtubule formation from two components separated by gel filtration of a tubulin preparation.

Authors:  T Haga; M Kurokawa
Journal:  Biochim Biophys Acta       Date:  1975-06-12

7.  Evidence for four classes of microtubules in individual cells.

Authors:  O Behnke; A Forer
Journal:  J Cell Sci       Date:  1967-06       Impact factor: 5.285

8.  The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein.

Authors:  G G Borisy; E W Taylor
Journal:  J Cell Biol       Date:  1967-08       Impact factor: 10.539

9.  The mechanism of action of colchicine. Colchicine binding properties of sea urchin sperm tail outer doublet tubulin.

Authors:  L Wilson; I Meza
Journal:  J Cell Biol       Date:  1973-09       Impact factor: 10.539

10.  THE MECHANISM OF COLCHICINE INHIBITION OF MITOSIS. I. KINETICS OF INHIBITION AND THE BINDING OF H3-COLCHICINE.

Authors:  E W TAYLOR
Journal:  J Cell Biol       Date:  1965-04       Impact factor: 10.539
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  61 in total

1.  Chlamydial antigens colocalize within IncA-laden fibers extending from the inclusion membrane into the host cytosol.

Authors:  W J Brown; Y A W Skeiky; P Probst; D D Rockey
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

2.  Control of microtubule assembly-disassembly by calcium-dependent regulator protein.

Authors:  J M Marcum; J R Dedman; B R Brinkley; A R Means
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

3.  A molecular and structural mechanism for G protein-mediated microtubule destabilization.

Authors:  Rahul H Davé; Witchuda Saengsawang; Manu Lopus; Sonya Davé; Leslie Wilson; Mark M Rasenick
Journal:  J Biol Chem       Date:  2010-11-26       Impact factor: 5.157

4.  Tubulin-isotype analysis of two grass species-resistant to dinitroaniline herbicides.

Authors:  T R Waldin; J R Ellis; P J Hussey
Journal:  Planta       Date:  1992-09       Impact factor: 4.116

5.  Rapid and Reversible High-Affinity Binding of the Dinitroaniline Herbicide Oryzalin to Tubulin from Zea mays L.

Authors:  J. D. Hugdahl; L. C. Morejohn
Journal:  Plant Physiol       Date:  1993-07       Impact factor: 8.340

6.  Cytoskeletal requirements in Chlamydia trachomatis infection of host cells.

Authors:  N Schramm; P B Wyrick
Journal:  Infect Immun       Date:  1995-01       Impact factor: 3.441

7.  Respective roles of neurofilaments, microtubules, MAP1B, and tau in neurite outgrowth and stabilization.

Authors:  T B Shea; M L Beermann
Journal:  Mol Biol Cell       Date:  1994-08       Impact factor: 4.138

8.  Effects of griseofulvin on mitosis in PtK1 cells.

Authors:  J M Mullins; J A Snyder
Journal:  Chromosoma       Date:  1979-04-05       Impact factor: 4.316

9.  Involvement of cytoskeletal structures in nerve-growth-factor-mediated induction of ornithine decarboxylase.

Authors:  J Lakshmanan
Journal:  Biochem J       Date:  1979-01-15       Impact factor: 3.857

10.  Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon.

Authors:  A M Northover; B J Northover
Journal:  Agents Actions       Date:  1993-07
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