| Literature DB >> 26940520 |
Cortney Chelise Winkle1, Stephanie L Gupton2.
Abstract
During development, neurons progress through rapid yet stereotypical shape changes to achieve proper neuronal connectivity. This morphological progression requires carefully orchestrated plasma membrane expansion, insertion of membrane components including receptors for extracellular cues into the plasma membrane and removal and trafficking of membrane materials and proteins to specific locations. This review outlines the cellular machinery of membrane trafficking that play an integral role in neuronal cell shape change and function from initial neurite formation to pathway navigation and synaptogenesis.Entities:
Keywords: Golgi apparatus; Golgi outposts; endocytosis; endoplasmic reticulum; exocytosis; membrane trafficking; neuron; neuronal development
Mesh:
Year: 2016 PMID: 26940520 PMCID: PMC4797321 DOI: 10.1016/bs.ircmb.2015.10.003
Source DB: PubMed Journal: Int Rev Cell Mol Biol ISSN: 1937-6448 Impact factor: 6.813