Navneet Kumar1,2, Pawan Kumar Maurya3,4, Ruchi Kant5, Syed Ibrahim Rizvi2. 1. a School of Medicine, College of Medicine and Health Sciences, Wollo University , Dessie , Ethiopia . 2. b Department of Biochemistry , University of Allahabad , Allahabad , Uttar Pradesh , India . 3. c Interdisciplinary Laboratory of Clinical Neuroscience (LiNC), Department of Psychiatry, Federal University of São Paulo , São Paulo , Brazil . 4. d Amity Institute of Biotechnology, Amity University , Noida , Uttar Pradesh , India , and. 5. e Department of Chemistry , College of Natural Science, Wollo University , Dessie , Ethiopia.
Abstract
CONTEXT: Oxidative stress plays a key role in the patho-physiology of hypertension. (-)-Epicatechin has many important biological properties. OBJECTIVE: The present study was undertaken to evaluate effect of (-)-epicatechin on protein carbonyl content in gender-based hypertensive patients and normal subjects. METHODS: The study was carried out on 83 normal (male: 42; female: 41) and 62 hypertensive subjects (male: 32; female: 30). In vitro effect on (-)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content. RESULTS: Result showed a significant (p < 0.001) increase in protein carbonyl content in hypertensive patients but no gender-based difference was observed. (-)-epicatechin shows significant (p < 0.001) dose-dependent effect as compared to L-ascorbic acid, which is manifested as decrease in protein carbonyl content. CONCLUSION: We hypothesizes that a higher intake of (-)-epicatechin may provide protection against hypertension in males and females.
CONTEXT: Oxidative stress plays a key role in the patho-physiology of hypertension. (-)-Epicatechin has many important biological properties. OBJECTIVE: The present study was undertaken to evaluate effect of (-)-epicatechin on protein carbonyl content in gender-based hypertensivepatients and normal subjects. METHODS: The study was carried out on 83 normal (male: 42; female: 41) and 62 hypertensive subjects (male: 32; female: 30). In vitro effect on (-)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content. RESULTS: Result showed a significant (p < 0.001) increase in protein carbonyl content in hypertensivepatients but no gender-based difference was observed. (-)-epicatechin shows significant (p < 0.001) dose-dependent effect as compared to L-ascorbic acid, which is manifested as decrease in protein carbonyl content. CONCLUSION: We hypothesizes that a higher intake of (-)-epicatechin may provide protection against hypertension in males and females.