Christa Lykke Christensen1, Jørn Wulff Helge2, Allan Krasnik3, Margit Kriegbaum3, Lene Juel Rasmussen4, Ian D Hickson4, Kasper Bering Liisberg1, Bjarke Oxlund5, Birgitte Bruun5, Sofie Rosenlund Lau5, Maria Nathalie Angleys Olsen4, John Sahl Andersen6, Andreas Søndergaard Heltberg6, Anja Birk Kuhlman2, Thomas Hoffmann Morville2, Tine Lovsø Dohlmann2, Steen Larsen2, Flemming Dela7. 1. Section of Film, Media and Communication, Department of Media, Cognition and Communication, Faculty of the Humanities, University of Copenhagen, Denmark. 2. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark. 3. Section of Health Services Research, Department of Public Health, Faculty of Health and Medicine, University of Copenhagen, Denmark. 4. Center for Healthy Aging, Department of Cellular and Molecular Medicine, Faculty of Health and Medicine, University of Copenhagen, Denmark. 5. Department of Anthropology, Faculty of Social Sciences, University of Copenhagen, Denmark. 6. Section of General Practice, Department of Public Health, Faculty of Health and Medicine, University of Copenhagen, Denmark. 7. Xlab, Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medicine, University of Copenhagen, Denmark fdela@sund.ku.dk.
Abstract
AIM: LIFESTAT is an interdisciplinary project that leverages approaches and knowledge from medicine, the humanities and the social sciences to analyze the impact of statin use on health, lifestyle and well-being in cohorts of Danish citizens. The impetus for the study is the fact that 10% of the population in the Scandinavian countries are treated with statins in order to maintain good health and to avoid cardiovascular disease by counteracting high blood levels of cholesterol. The potential benefit of treatment with statins should be considered in light of evidence that statin use has prevalent and unintended side effects (e.g. myalgia, and glucose and exercise intolerance). METHODS: The LIFESTAT project combines invasive human experiments, biomedical analyses, nationwide surveys, epidemiological studies, qualitative interviews, media content analyses, and ethnographic participant observations. The study investigates the biological consequences of statin treatment; determines the mechanism(s) by which statin use causes muscle and mitochondrial dysfunction; and analyzes achievement of treatment goals, people's perception of disease risk, media influence on people's risk and health perception, and the way people manage to live with the risk (personally, socially and technologically). CONCLUSIONS THE ORIGINALITY AND SUCCESS OF LIFESTAT DEPEND ON AND DERIVE FROM ITS INTERDISCIPLINARY APPROACH, IN WHICH THE DISCIPLINES CONVERGE INTO THOROUGH AND HOLISTIC STUDY AND DESCRIBE THE IMPACT OF STATIN USE ON THE EVERYDAY LIFE OF STATIN USERS THIS HAS THE POTENTIAL FOR MUCH GREATER BENEFIT THAN ANY ONE OF THE DISCIPLINES ALONE INTEGRATING TRADITIONAL DISCIPLINES PROVIDES NOVEL PERSPECTIVES ON POTENTIAL CURRENT AND FUTURE SOCIAL, MEDICAL AND PERSONAL BENEFITS OF STATIN USE.
AIM: LIFESTAT is an interdisciplinary project that leverages approaches and knowledge from medicine, the humanities and the social sciences to analyze the impact of statin use on health, lifestyle and well-being in cohorts of Danish citizens. The impetus for the study is the fact that 10% of the population in the Scandinavian countries are treated with statins in order to maintain good health and to avoid cardiovascular disease by counteracting high blood levels of cholesterol. The potential benefit of treatment with statins should be considered in light of evidence that statin use has prevalent and unintended side effects (e.g. myalgia, and glucose and exercise intolerance). METHODS: The LIFESTAT project combines invasive human experiments, biomedical analyses, nationwide surveys, epidemiological studies, qualitative interviews, media content analyses, and ethnographic participant observations. The study investigates the biological consequences of statin treatment; determines the mechanism(s) by which statin use causes muscle and mitochondrial dysfunction; and analyzes achievement of treatment goals, people's perception of disease risk, media influence on people's risk and health perception, and the way people manage to live with the risk (personally, socially and technologically). CONCLUSIONS THE ORIGINALITY AND SUCCESS OF LIFESTAT DEPEND ON AND DERIVE FROM ITS INTERDISCIPLINARY APPROACH, IN WHICH THE DISCIPLINES CONVERGE INTO THOROUGH AND HOLISTIC STUDY AND DESCRIBE THE IMPACT OF STATIN USE ON THE EVERYDAY LIFE OF STATIN USERS THIS HAS THE POTENTIAL FOR MUCH GREATER BENEFIT THAN ANY ONE OF THE DISCIPLINES ALONE INTEGRATING TRADITIONAL DISCIPLINES PROVIDES NOVEL PERSPECTIVES ON POTENTIAL CURRENT AND FUTURE SOCIAL, MEDICAL AND PERSONAL BENEFITS OF STATIN USE.
Authors: Ricardo Mora-Rodriguez; Juan Fernando Ortega; Felix Morales-Palomo; Miguel Ramirez-Jimenez; Alfonso Moreno-Cabañas Journal: Br J Clin Pharmacol Date: 2020-02-18 Impact factor: 4.335