Izel Tekin1, Angeliki Vgontzas2, Mechelle M Lewis3, Saira Kothari4, Lan Kong5, Yue Lu6, Kent E Vrana1, Xuemei Huang7. 1. Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA. 2. Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA. 3. Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA. 4. Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA. 5. Department of Public Health Sciences Pennsylvania State University College of Medicine, Hershey, PA, USA. 6. Department of Kinesiology, Statistics8 Pennsylvania State University, University Park, PA, USA. 7. Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Kinesiology, Pennsylvania State University, University Park, PA, USA.
Abstract
BACKGROUND: Parkinson's disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear. OBJECTIVE: To explore whether peripheral injury and associated chronic limb pain may influence the side of onset. METHODS: We administered a questionnaire to 128 PD patients in a tertiary movement disorder clinic. Handedness, date and type of limb injury(s) and duration of associated pain, and date and side of onset were ascertained. RESULTS: Sixty-two subjects reported limb injuries prior to the onset of PD symptoms, 30 with and 32 without chronic pain (i.e., ≥ 2 months). There was no association between injury and PD onset side overall (p=0.334). In subjects with chronic pain associated with limb injuries, however, side of injuries was associated with the side of PD symptom onset (p=0.030). CONCLUSIONS: Limb injury with chronic pain may be related to the side of PD symptom onset. Future studies may shed light on the nature of this observation.
BACKGROUND:Parkinson's disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear. OBJECTIVE: To explore whether peripheral injury and associated chronic limb pain may influence the side of onset. METHODS: We administered a questionnaire to 128 PDpatients in a tertiary movement disorder clinic. Handedness, date and type of limb injury(s) and duration of associated pain, and date and side of onset were ascertained. RESULTS: Sixty-two subjects reported limb injuries prior to the onset of PD symptoms, 30 with and 32 without chronic pain (i.e., ≥ 2 months). There was no association between injury and PD onset side overall (p=0.334). In subjects with chronic pain associated with limb injuries, however, side of injuries was associated with the side of PD symptom onset (p=0.030). CONCLUSIONS:Limb injury with chronic pain may be related to the side of PD symptom onset. Future studies may shed light on the nature of this observation.
Entities:
Keywords:
Handedness; Parkinson's disease; Peripheral limb injury; Side of onset