BACKGROUND: GLUTs are a family of proteins that mediate glucose transport through the membrane, expressed in head and neck squamous cell carcinoma. GLUT-1 positivity in malignant cells indicates increased proliferative activity, energy requirements, aggressive behaviour and poor radiation response. AIM: To observe the expression of GLUT-1 protein in oral squamous cell carcinoma in tobacco and non-tobacco users and to correlate the expression with histopathological grading and pathological staging. METHODS: 50 cases (25 tobacco and 25 non-tobacco) of oral squamous cell carcinoma, selected during period of August 2014 to July 2015. Histopathological grading, TNM and staging were done. Immunohistochemical staining was performed using standard protocol for paraffin embedded sections. Analysis was performed on SPSS software (Windows version 17.0). RESULTS: Significant association of GLUT-1 expression was found with history of tobacco (p < 0.001), Bryne's grade (p < 0.001), tumour size (p = 0.001), nodal metastasis (p = 0.022) and stage (p < 0.001). Higher GLUT-1 expression in stage II, stage III and stage IV was found as compared to stage I. GLUT-1 immunoexpression also shows progressive switch from membranous to cytoplasmic to combined location correlating with histopathologic grade and pTNM stage. CONCLUSION: GLUT-1 expression correlates significantly with histological grade and pTNM staging of oral squamous cell carcinoma. It also significantly correlates with tobacco addiction. Thus, GLUT-1 expression may serve as a biomarker for patients of oral squamous cell carcinoma.
BACKGROUND: GLUTs are a family of proteins that mediate glucose transport through the membrane, expressed in head and neck squamous cell carcinoma. GLUT-1 positivity in malignant cells indicates increased proliferative activity, energy requirements, aggressive behaviour and poor radiation response. AIM: To observe the expression of GLUT-1 protein in oral squamous cell carcinoma in tobacco and non-tobacco users and to correlate the expression with histopathological grading and pathological staging. METHODS: 50 cases (25 tobacco and 25 non-tobacco) of oral squamous cell carcinoma, selected during period of August 2014 to July 2015. Histopathological grading, TNM and staging were done. Immunohistochemical staining was performed using standard protocol for paraffin embedded sections. Analysis was performed on SPSS software (Windows version 17.0). RESULTS: Significant association of GLUT-1 expression was found with history of tobacco (p < 0.001), Bryne's grade (p < 0.001), tumour size (p = 0.001), nodal metastasis (p = 0.022) and stage (p < 0.001). Higher GLUT-1 expression in stage II, stage III and stage IV was found as compared to stage I. GLUT-1 immunoexpression also shows progressive switch from membranous to cytoplasmic to combined location correlating with histopathologic grade and pTNM stage. CONCLUSION:GLUT-1 expression correlates significantly with histological grade and pTNM staging of oral squamous cell carcinoma. It also significantly correlates with tobacco addiction. Thus, GLUT-1 expression may serve as a biomarker for patients of oral squamous cell carcinoma.
Authors: Alexander W Eckert; Matthias H W Lautner; Andreas Schütze; Helge Taubert; Johannes Schubert; Udo Bilkenroth Journal: Histopathology Date: 2011-03-25 Impact factor: 5.087
Authors: Kátia C Carvalho; Isabela W Cunha; Rafael M Rocha; Fernanda R Ayala; Mariana M Cajaíba; Maria D Begnami; Rafael S Vilela; Geise R Paiva; Rodrigo G Andrade; Fernando A Soares Journal: Clinics (Sao Paulo) Date: 2011 Impact factor: 2.365
Authors: Christian Rudlowski; Albert J Becker; Willibald Schroder; Werner Rath; Reinhard Büttner; Markus Moser Journal: Am J Clin Pathol Date: 2003-11 Impact factor: 2.493
Authors: Yoon Seok Choi; Seok Jin Kim; Dae Sik Kim; Seh Jong Park; Yong Park; Hye Jin Shin; Kwang-Yoon Jung; Seung-Kuk Baek; Bong Kyung Shin; Jung Woo Choi; Byung Soo Kim; Sang Won Shin; Yeul Hong Kim; Jun Suk Kim Journal: Cancer Res Treat Date: 2007-09-30 Impact factor: 4.679
Authors: Omar Hasan Ali; Stefan Diem; Josef Aschwanden; Eva Markert; Abel-Jan Tasman; Joachim Mueller; Lukas Flatz Journal: JAAD Case Rep Date: 2016-10-13
Authors: Catherine A Hess; Tamar M J Antin; Rachelle Annechino; Geoffrey Hunt Journal: Int J Environ Res Public Health Date: 2017-01-11 Impact factor: 3.390