Charles R Esther1, Rongpong Plongla2, Alan Kerr3, Feng-Chang Lin4, Peter Gilligan3. 1. Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. Electronic address: Charles_Esther@med.unc.edu. 2. Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Infectious Diseases, King Chulalongkorn Memorial Hospital and Chulalongkorn University, Bangkok, Thailand 10330. 3. Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599. 4. Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Abstract
BACKGROUND: Relationships between clinical outcomes and novel respiratory pathogens such as Trichosporon are not well understood. METHODS: Respiratory cultures from CF patients were screened for novel pathogens Trichosporon and Chryseobacterium as well as other pathogens over 28months. Relationships between microbiologic and clinical data were assessed using univariate and multivariate methods. RESULTS: Of 4934 respiratory cultures from 474 CF patients, 37 cultures from 10 patients were Trichosporon positive. Patients with positive Trichosproron cultures had a greater decline in FEV1 over time (-3.9%/year vs. -1.3%/year, p<0.05), whereas Chryseobacterium did not influence lung function. These findings were confirmed in multivariate analyses that included age, gender, and other common pathogens as confounders. Treatment of Trichosporon infected patients was associated with improved lung function. CONCLUSIONS: Trichosporon can be recovered from a small but clinically meaningful fraction of CF patients. The presence of Trichosporon, but not Chryseobacterium, is associated with greater declines in lung function.
BACKGROUND: Relationships between clinical outcomes and novel respiratory pathogens such as Trichosporon are not well understood. METHODS: Respiratory cultures from CFpatients were screened for novel pathogens Trichosporon and Chryseobacterium as well as other pathogens over 28months. Relationships between microbiologic and clinical data were assessed using univariate and multivariate methods. RESULTS: Of 4934 respiratory cultures from 474 CFpatients, 37 cultures from 10 patients were Trichosporon positive. Patients with positive Trichosproron cultures had a greater decline in FEV1 over time (-3.9%/year vs. -1.3%/year, p<0.05), whereas Chryseobacterium did not influence lung function. These findings were confirmed in multivariate analyses that included age, gender, and other common pathogens as confounders. Treatment of Trichosporon infectedpatients was associated with improved lung function. CONCLUSIONS: Trichosporon can be recovered from a small but clinically meaningful fraction of CFpatients. The presence of Trichosporon, but not Chryseobacterium, is associated with greater declines in lung function.
Authors: Gina Hong; Heather B Miller; Sarah Allgood; Richard Lee; Noah Lechtzin; Sean X Zhang Journal: J Clin Microbiol Date: 2017-01-18 Impact factor: 5.948
Authors: João Nobrega de Almeida; Elaine Cristina Francisco; Maria Goreth M de Andrade Barberino; Luiz Vicente Ribeiro F da Silva; Oriana M Brandão; Arnaldo Lopes Colombo; Ana Carolina Barbosa Padovan Journal: Mem Inst Oswaldo Cruz Date: 2017-10 Impact factor: 2.743
Authors: Juan de Dios Caballero; Rafael Cantón; Manuel Ponce-Alonso; Marta María García-Clemente; Elia Gómez G de la Pedrosa; José Luis López-Campos; Luis Máiz; Rosa Del Campo; Miguel Ángel Martínez-García Journal: Microorganisms Date: 2022-04-13