Eugene S J Tan1, Jonathan Yap2, Chang Fen Xu1, Liang Feng3, Shwe Zin Nyunt3, Rajalakshmi Santhanakrishnan4, Michelle M Y Chan5, Swee Chong Seow1, Chi Keong Ching6, Khung Keong Yeo6, A Mark Richards7, Tze Pin Ng3, Toon Wei Lim1, Carolyn S P Lam8. 1. National University Heart Centre, Singapore. 2. National Heart Centre Singapore, Singapore. 3. National University of Singapore, Singapore. 4. Section of Cardiovascular Medicine, Boston University, Boston, MA, USA. 5. SingHealth Internal Medicine Residency Program, Singapore Health Services, Singapore. 6. National Heart Centre Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore. 7. National University Heart Centre, Singapore; Cardiovascular Research Institute, National University Health System, Singapore; Christchurch Heart Institute, University of Otago, Otago, New Zealand. 8. National Heart Centre Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore. Electronic address: carolyn.lam@duke-nus.edu.sg.
Abstract
BACKGROUND: Existing electrocardiographic (ECG) reference values were derived in middle-aged Caucasian adults. We aimed to assess the association of age, sex, body size and ethnicity on ECG parameters in a multi-ethnic Asian population. METHODS: Resting 12-lead ECG and anthropometric measurements were performed in a community-based cohort of 3777 older Asians (age 64.7±9.1 years, 1467 men, 88.8% Chinese, 7.7% Malay, 3.5% Indian, body mass index [BMI] 24.0±3.9kg/m(2)). RESULTS: Men had longer PR interval, wider QRS, shorter QTc interval and taller SV3. In both sexes, older age was associated with longer PR interval, wider QRS, larger R aVL and more leftward QRS axis, while higher BMI was associated with longer PR interval, wider QRS, larger RaVL and more negative QRS axis. There were significant inter-ethnic differences in QRS duration among men, as well as in PR and QTc intervals among women (all adjusted p<0.05). Findings were similar in a healthy subset of 1158 adults (age 61.2±9.1 years, 365 men) without cardiovascular risk factors. CONCLUSIONS: These first community-based ECG data in multi-ethnic older Asians highlight the independent effects of age, sex, body size and ethnicity on ECG parameters.
BACKGROUND: Existing electrocardiographic (ECG) reference values were derived in middle-aged Caucasian adults. We aimed to assess the association of age, sex, body size and ethnicity on ECG parameters in a multi-ethnic Asian population. METHODS: Resting 12-lead ECG and anthropometric measurements were performed in a community-based cohort of 3777 older Asians (age 64.7±9.1 years, 1467 men, 88.8% Chinese, 7.7% Malay, 3.5% Indian, body mass index [BMI] 24.0±3.9kg/m(2)). RESULTS:Men had longer PR interval, wider QRS, shorter QTc interval and taller SV3. In both sexes, older age was associated with longer PR interval, wider QRS, larger R aVL and more leftward QRS axis, while higher BMI was associated with longer PR interval, wider QRS, larger RaVL and more negative QRS axis. There were significant inter-ethnic differences in QRS duration among men, as well as in PR and QTc intervals among women (all adjusted p<0.05). Findings were similar in a healthy subset of 1158 adults (age 61.2±9.1 years, 365 men) without cardiovascular risk factors. CONCLUSIONS: These first community-based ECG data in multi-ethnic older Asians highlight the independent effects of age, sex, body size and ethnicity on ECG parameters.
Authors: Janice Y Chyou; Wan Ting Tay; Inder S Anand; Tiew-Hwa Katherine Teng; Jonathan J L Yap; Michael R MacDonald; Vijay Chopra; Seet Yoong Loh; Wataru Shimizu; Imran Zainal Abidin; Arthur Mark Richards; Javed Butler; Carolyn S P Lam Journal: J Am Heart Assoc Date: 2021-03-13 Impact factor: 5.501