Literature DB >> 26934309

Transcriptional enhancers: Transcription, function and flexibility.

Philippa Melamed1, Yahav Yosefzon1, Sergei Rudnizky1, Lilach Pnueli1.   

Abstract

Active transcriptional enhancers are often transcribed to eRNAs, whose changing levels mirror those of the target gene mRNA. We discuss some of the reported functions of these eRNAs and their likely diversity to allow utilization of distinct cis regulatory regions to enhance transcription in diverse developmental and cellular contexts.

Keywords:  chromatin; eRNA; enhancer; histone modification; non-coding RNA; promoter; transcription

Mesh：

Substances：

Year:  2016        PMID： 26934309      PMCID： PMC4802784          DOI： 10.1080/21541264.2015.1128517

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  38 in total

1.  Enhancer RNA facilitates NELF release from immediate early genes.

Authors:  Katie Schaukowitch; Jae-Yeol Joo; Xihui Liu; Jonathan K Watts; Carlos Martinez; Tae-Kyung Kim
Journal:  Mol Cell       Date:  2014-09-25       Impact factor: 17.970

2.  What are super-enhancers?

Authors:  Sebastian Pott; Jason D Lieb
Journal:  Nat Genet       Date:  2015-01       Impact factor: 38.330

Review 3.  Transcriptional enhancers: from properties to genome-wide predictions.

Authors:  Daria Shlyueva; Gerald Stampfel; Alexander Stark
Journal:  Nat Rev Genet       Date:  2014-03-11       Impact factor: 53.242

Review 4.  Enhancer RNAs and regulated transcriptional programs.

Authors:  Michael T Y Lam; Wenbo Li; Michael G Rosenfeld; Christopher K Glass
Journal:  Trends Biochem Sci       Date:  2014-03-24       Impact factor: 13.807

5.  Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation.

Authors:  Chen-Lin Hsieh; Teng Fei; Yiwen Chen; Tiantian Li; Yanfei Gao; Xiaodong Wang; Tong Sun; Christopher J Sweeney; Gwo-Shu Mary Lee; Shaoyong Chen; Steven P Balk; Xiaole Shirley Liu; Myles Brown; Philip W Kantoff
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-28       Impact factor: 11.205

Review 6.  Enhancer function: mechanistic and genome-wide insights come together.

Authors:  Jennifer L Plank; Ann Dean
Journal:  Mol Cell       Date:  2014-07-03       Impact factor: 17.970

7.  An atlas of active enhancers across human cell types and tissues.

Authors:  Robin Andersson; Claudia Gebhard; Michael Rehli; Albin Sandelin; Irene Miguel-Escalada; Ilka Hoof; Jette Bornholdt; Mette Boyd; Yun Chen; Xiaobei Zhao; Christian Schmidl; Takahiro Suzuki; Evgenia Ntini; Erik Arner; Eivind Valen; Kang Li; Lucia Schwarzfischer; Dagmar Glatz; Johanna Raithel; Berit Lilje; Nicolas Rapin; Frederik Otzen Bagger; Mette Jørgensen; Peter Refsing Andersen; Nicolas Bertin; Owen Rackham; A Maxwell Burroughs; J Kenneth Baillie; Yuri Ishizu; Yuri Shimizu; Erina Furuhata; Shiori Maeda; Yutaka Negishi; Christopher J Mungall; Terrence F Meehan; Timo Lassmann; Masayoshi Itoh; Hideya Kawaji; Naoto Kondo; Jun Kawai; Andreas Lennartsson; Carsten O Daub; Peter Heutink; David A Hume; Torben Heick Jensen; Harukazu Suzuki; Yoshihide Hayashizaki; Ferenc Müller; Alistair R R Forrest; Piero Carninci
Journal:  Nature       Date:  2014-03-27       Impact factor: 49.962

8.  Integrative analysis of haplotype-resolved epigenomes across human tissues.

Authors:  Danny Leung; Inkyung Jung; Nisha Rajagopal; Anthony Schmitt; Siddarth Selvaraj; Ah Young Lee; Chia-An Yen; Shin Lin; Yiing Lin; Yunjiang Qiu; Wei Xie; Feng Yue; Manoj Hariharan; Pradipta Ray; Samantha Kuan; Lee Edsall; Hongbo Yang; Neil C Chi; Michael Q Zhang; Joseph R Ecker; Bing Ren
Journal:  Nature       Date:  2015-02-19       Impact factor: 49.962

9.  Epigenetic modifications are associated with inter-species gene expression variation in primates.

Authors:  Xiang Zhou; Carolyn E Cain; Marsha Myrthil; Noah Lewellen; Katelyn Michelini; Emily R Davenport; Matthew Stephens; Jonathan K Pritchard; Yoav Gilad
Journal:  Genome Biol       Date:  2014       Impact factor: 13.583

10.  B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.

Authors:  Jason Qian; Qiao Wang; Marei Dose; Nathanael Pruett; Kyong-Rim Kieffer-Kwon; Wolfgang Resch; Genqing Liang; Zhonghui Tang; Ewy Mathé; Christopher Benner; Wendy Dubois; Steevenson Nelson; Laura Vian; Thiago Y Oliveira; Mila Jankovic; Ofir Hakim; Anna Gazumyan; Rushad Pavri; Parirokh Awasthi; Bin Song; Geng Liu; Longyun Chen; Shida Zhu; Lionel Feigenbaum; Louis Staudt; Cornelis Murre; Yijun Ruan; Davide F Robbiani; Qiang Pan-Hammarström; Michel C Nussenzweig; Rafael Casellas
Journal:  Cell       Date:  2014-12-04       Impact factor: 41.582
View more
  9 in total

1.  Unraveling the mechanisms of chromatin fibril packaging.

Authors:  Alexey A Gavrilov; Yuri Y Shevelyov; Sergey V Ulianov; Ekaterina E Khrameeva; Pavel Kos; Alexander Chertovich; Sergey V Razin
Journal:  Nucleus       Date:  2016-05-03       Impact factor: 4.197

2.  EpiAlign: an alignment-based bioinformatic tool for comparing chromatin state sequences.

Authors:  Xinzhou Ge; Haowen Zhang; Lingjue Xie; Wei Vivian Li; Soo Bin Kwon; Jingyi Jessica Li
Journal:  Nucleic Acids Res       Date:  2019-07-26       Impact factor: 16.971

3.  Analysis of the landscape of human enhancer sequences in biological databases.

Authors:  Juan Mulero Hernández; Jesualdo Tomás Fernández-Breis
Journal:  Comput Struct Biotechnol J       Date:  2022-05-30       Impact factor: 6.155

4.  An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis.

Authors:  Yahav Yosefzon; Cfir David; Anna Tsukerman; Lilach Pnueli; Sen Qiao; Ulrich Boehm; Philippa Melamed
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-30       Impact factor: 11.205

Review 5.  Multifaceted Targeting of the Chromatin Mediates Gonadotropin-Releasing Hormone Effects on Gene Expression in the Gonadotrope.

Authors:  Philippa Melamed; Majd Haj; Yahav Yosefzon; Sergei Rudnizky; Andrea Wijeweera; Lilach Pnueli; Ariel Kaplan
Journal:  Front Endocrinol (Lausanne)       Date:  2018-02-27       Impact factor: 5.555

Review 6.  The Unforeseen Non-Coding RNAs in Head and Neck Cancer.

Authors:  Alexandra Iulia Irimie; Alina-Andreea Zimta; Cristina Ciocan; Nikolay Mehterov; Diana Dudea; Cornelia Braicu; Ioana Berindan-Neagoe
Journal:  Genes (Basel)       Date:  2018-03-01       Impact factor: 4.096

7.  Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.

Authors:  Ben Bar-Sadeh; Or E Amichai; Lilach Pnueli; Khurshida Begum; Gregory Leeman; Richard D Emes; Reinhard Stöger; Gillian R Bentley; Philippa Melamed
Journal:  BMC Biol       Date:  2022-01-07       Impact factor: 7.431

8.  Testing Proximity of Genomic Regions to Transcription Start Sites and Enhancers Complements Gene Set Enrichment Testing.

Authors:  Christopher Lee; Kai Wang; Tingting Qin; Maureen A Sartor
Journal:  Front Genet       Date:  2020-03-06       Impact factor: 4.599

Review 9.  Enhancing Gonadotrope Gene Expression Through Regulatory lncRNAs.

Authors:  Tal Refael; Philippa Melamed
Journal:  Endocrinology       Date:  2021-08-01       Impact factor: 4.736
  9 in total

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