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Literature DB >> 26934308

Insights into centromeric transcription in mitosis.

Abstract

The major role of RNA polymerase II (RNAP II) is to generate mRNAs. I recently uncovered a novel function of RNAP II in chromosome segregation in mitosis, installing the cohesin protector, Shugoshin, at centromeres. Here I will discuss the current understanding of RNAP II-dependent centromeric transcription in mitosis.

Keywords: Bub1; RNA polymerase II; Sgo1; centromere; centromeric cohesion; kinetochore; mitosis; transcription

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Substances：

Year: 2016 PMID： 26934308 PMCID： PMC4802800 DOI： 10.1080/21541264.2015.1127315

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

28 in total

1. Active transcription and essential role of RNA polymerase II at the centromere during mitosis.

Authors: F Lyn Chan; Owen J Marshall; Richard Saffery; Bo Won Kim; Elizabeth Earle; K H Andy Choo; Lee H Wong
Journal: Proc Natl Acad Sci U S A Date: 2012-01-20 Impact factor: 11.205

Review 2. Pause, play, repeat: CDKs push RNAP II's buttons.

Authors: Miriam Sansó; Robert P Fisher
Journal: Transcription Date: 2013-06-11

3. Discovering centromere proteins: from cold white hands to the A, B, C of CENPs.

Authors: William C Earnshaw
Journal: Nat Rev Mol Cell Biol Date: 2015-05-20 Impact factor: 94.444

4. Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting.

Authors: Zhonghui Lin; Luying Jia; Diana R Tomchick; Xuelian Luo; Hongtao Yu
Journal: Structure Date: 2014-10-09 Impact factor: 5.006

Review 1. An emerging role of transcription in chromosome segregation: Ongoing centromeric transcription maintains centromeric cohesion.

Authors: Yujue Chen; Qian Zhang; Hong Liu
Journal: Bioessays Date: 2021-11-10 Impact factor: 4.345

2. Shoutai pills improve the quality of oocytes exposed to the chemotherapeutic drug Hydroxyurea.

Authors: Yuwei Zhang; Ruizhi Tan; Li Wang; Xiaoyan Shi; Yu Li; Xia Zhong; Xiaoxia He; Bo Xiong
Journal: Aging (Albany NY) Date: 2020-05-10 Impact factor: 5.682

2 in total

Insights into centromeric transcription in mitosis.

1. Active transcription and essential role of RNA polymerase II at the centromere during mitosis.

Review 2. Pause, play, repeat: CDKs push RNAP II's buttons.

3. Discovering centromere proteins: from cold white hands to the A, B, C of CENPs.

4. Substrate-specific activation of the mitotic kinase Bub1 through intramolecular autophosphorylation and kinetochore targeting.

5. The inner centromere-shugoshin network prevents chromosomal instability.

6. Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

7. Functional analysis of kinetochore assembly in Caenorhabditis elegans.

8. Sequence features and transcriptional stalling within centromere DNA promote establishment of CENP-A chromatin.

9. Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division.

10. Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.

Review 1. An emerging role of transcription in chromosome segregation: Ongoing centromeric transcription maintains centromeric cohesion.

2. Shoutai pills improve the quality of oocytes exposed to the chemotherapeutic drug Hydroxyurea.