BACKGROUND: New-onset diabetes after kidney transplantation (NODAT) is associated with both renal allograft failure and increased mortality. The objective of this meta-analysis was to evaluate the risk of NODAT in patients with hypomagnesemia. METHODS: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through May, 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of NODAT in patients with hypomagnesemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Five cohort studies with 1699 patients were included in the analysis to assess the risk of NODAT in patients with hypomagnesemia. The pooled RR of NODAT in patients with hypomagnesemia was 1.25 (95% CI, 1.08-1.45). When meta-analysis was limited only to studies with the post-transplant hypomagnesemia, the pooled RR of NODAT was 1.22 (95% CI, 1.09-1.38). CONCLUSION: Our meta-analysis demonstrates a significant association between hypomagnesemia and NODAT in kidney transplant recipients. This finding suggests the need for a large randomized controlled trial-with very careful attention to assess the effects of normalizing Mg levels and the risk of NODAT.
BACKGROUND: New-onset diabetes after kidney transplantation (NODAT) is associated with both renal allograft failure and increased mortality. The objective of this meta-analysis was to evaluate the risk of NODAT in patients with hypomagnesemia. METHODS: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through May, 2015. Studies that reported relative risks, odd ratios or hazard ratios comparing the risk of NODAT in patients with hypomagnesemia were included. Pooled risk ratios (RR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Five cohort studies with 1699 patients were included in the analysis to assess the risk of NODAT in patients with hypomagnesemia. The pooled RR of NODAT in patients with hypomagnesemia was 1.25 (95% CI, 1.08-1.45). When meta-analysis was limited only to studies with the post-transplant hypomagnesemia, the pooled RR of NODAT was 1.22 (95% CI, 1.09-1.38). CONCLUSION: Our meta-analysis demonstrates a significant association between hypomagnesemia and NODAT in kidney transplant recipients. This finding suggests the need for a large randomized controlled trial-with very careful attention to assess the effects of normalizing Mg levels and the risk of NODAT.
Authors: Nicola Veronese; Jacopo Demurtas; Gabriella Pesolillo; Stefano Celotto; Tommaso Barnini; Giovanni Calusi; Maria Gabriella Caruso; Maria Notarnicola; Rosa Reddavide; Brendon Stubbs; Marco Solmi; Stefania Maggi; Alberto Vaona; Joseph Firth; Lee Smith; Ai Koyanagi; Ligia Dominguez; Mario Barbagallo Journal: Eur J Nutr Date: 2019-01-25 Impact factor: 5.614
Authors: Wesley Hayes; Sheila Boyle; Adrian Carroll; Detlef Bockenhauer; Stephen D Marks Journal: Pediatr Nephrol Date: 2016-12-30 Impact factor: 3.714
Authors: Yael Peled; Eilon Ram; Jacob Lavee; Alexander Tenenbaum; Enrique Z Fisman; Dov Freimark; Robert Klempfner; Leonid Sternik; Michael Shechter Journal: Cardiovasc Diabetol Date: 2019-10-11 Impact factor: 9.951
Authors: Hyeon Seok Hwang; Kyung-Won Hong; Jin Sug Kim; Yang Gyun Kim; Ju Young Moon; Kyung Hwan Jeong; Sang Ho Lee Journal: J Clin Med Date: 2019-10-16 Impact factor: 4.241