Grażyna Adler1, Karolina Skonieczna-Żydecka1, Agnieszka Madlani1, Jarosław Ogonowski2, Elżbieta Grochans3, Joanna Pierzak-Sominka4, Jacek Brodowski5, Beata Karakiewicz6. 1. Department of Gerontobiology, Pomeranian Medical University, Szczecin, Szczecin, Poland. 2. Department of Civilization Diseases, Pomeranian Medical University, Szczecin, Poland. 3. Department of Nursing, Pomeranian Medical University, Szczecin, Poland. 4. Department of Public Health, Pomeranian Medical University, Szczecin, Poland. 5. Laboratory of Primary Health Care, Pomeranian Medical University, Szczecin, Poland. 6. Chair and Department of Public Health, Pomeranian Medical University, Szczecin, Poland.
Abstract
BACKGROUND: During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention. AIM: We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects. METHODS: A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used. RESULTS: A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R=0.135 and p=0.02, R=0.114 and p<0.05, respectively) was found. No association between studied polymorphisms and depression was observed. CONCLUSION: Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.
BACKGROUND: During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention. AIM: We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects. METHODS: A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used. RESULTS: A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R=0.135 and p=0.02, R=0.114 and p<0.05, respectively) was found. No association between studied polymorphisms and depression was observed. CONCLUSION: Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.
Authors: María Jesús Ramírez-Expósito; Basilio Dueñas-Rodríguez; María Pilar Carrera-González; Joaquín Navarro-Cecilia; José Manuel Martínez-Martos Journal: Compr Psychoneuroendocrinol Date: 2021-01-23