Literature DB >> 26933743

The Intersection of Structural and Chemical Biology - An Essential Synergy.

William J Zuercher1, Jonathan M Elkins2, Stefan Knapp3.   

Abstract

The continual improvement in our ability to generate high resolution structural models of biological molecules has stimulated and supported innovative chemical biology projects that target increasingly challenging ligand interaction sites. In this review we outline some of the recent developments in chemical biology and rational ligand design and show selected examples that illustrate the synergy between these research areas.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 26933743     DOI： 10.1016/j.chembiol.2015.12.005

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  3 in total

1.  Cloning, Expression, Purification, Crystallization, and X-Ray Structural Determination of the Human NQO2 in Complex with Melatonin.

Authors:  Barbara Calamini; Gilles Ferry; Jean A Boutin
Journal:  Methods Mol Biol       Date:  2022

2.  Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.

Authors:  Callum F Lawrence; Mai B Margetts; John G Menting; Nicholas A Smith; Brian J Smith; Colin W Ward; Michael C Lawrence
Journal:  J Biol Chem       Date:  2016-06-08       Impact factor: 5.157

3.  Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.

Authors:  Yann Ferrandez; Wenhua Zhang; François Peurois; Lurlène Akendengué; Anne Blangy; Mahel Zeghouf; Jacqueline Cherfils
Journal:  Sci Rep       Date:  2017-10-31       Impact factor: 4.379
  3 in total

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