Ian Postuma1, Silva Bortolussi1, Nicoletta Protti1, Francesca Ballarini1, Piero Bruschi2, Laura Ciani3, Sandra Ristori3, Luigi Panza4, Cinzia Ferrari5, Laura Cansolino5, Saverio Altieri1. 1. Department of Physics, University of Pavia, Italy; National Institute of Nuclear Physics, INFN, Section of Pavia, Italy. 2. Department of Physics, University of Pavia, Italy. 3. Department of Chemistry 'UgoSchi' & CSGI, University of Florence, Florence, Italy. 4. DISCAFF, University of Eastern Piedmont, Novara, Italy. 5. Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Universit degli Studidi Pavia, Italy.
Abstract
AIM: Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA). BACKGROUND: Therefore, a (10)B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations. MATERIALS AND METHODS: This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions. RESULTS: Calibration curves for both liquid and tissue samples were obtained. CONCLUSIONS: The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.
AIM: Boron Neutron Capture Therapy (BNCT) is a binary hadrontherapy which exploits the neutron capture reaction in boron, together with a selective uptake of boronated substances by the neoplastic tissue. There is increasing evidence that future improvements in clinical BNCT will be triggered by the discovery of new boronated compounds, with higher selectivity for the tumor with respect to clinically used sodium borocaptate (BSH) and boronophenylalanine (BPA). BACKGROUND: Therefore, a (10)B quantification technique for biological samples is needed in order to evaluate the performance of new boronated formulations. MATERIALS AND METHODS: This article describes an improved neutron autoradiography set-up employing radiation sensitive films where the latent tracks are made visible by proper etching conditions. RESULTS: Calibration curves for both liquid and tissue samples were obtained. CONCLUSIONS: The obtained calibration curves were adopted to set-up a mechanism to point out boron concentration in the whole sample.
Authors: Ana J Molinari; Silvia I Thorp; Agustina M Portu; Gisela Saint Martin; Emiliano C C Pozzi; Elisa M Heber; Silva Bortolussi; Maria E Itoiz; Romina F Aromando; Andrea Monti Hughes; Marcela A Garabalino; Saverio Altieri; Verónica A Trivillin; Amanda E Schwint Journal: Acta Oncol Date: 2014-06-24 Impact factor: 4.089
Authors: S Altieri; S Bortolussi; P Bruschi; P Chiari; F Fossati; S Stella; U Prati; L Roveda; A Zonta; C Zonta; C Ferrari; A Clerici; R Nano; T Pinelli Journal: Appl Radiat Isot Date: 2008-05-29 Impact factor: 1.513