Ferdane Sapmaz1, Sebahat Başyiğit2, İsmail Hakkı Kalkan3, Üçler Kısa4, Engin Eren Kavak3, Sefa Güliter3. 1. Department of Gastroenterology, Keçiören Education and Training Hospital, Keçiören, Ankara, Turkey. ferda-sapmaz@hotmail.com. 2. Department of Gastroenterology, Keçiören Education and Training Hospital, Keçiören, Ankara, Turkey. 3. Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey. 4. Department of Biochemistry, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
Abstract
BACKGROUND AND AIM: The aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection. METHODS: The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits. RESULTS: There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001). CONCLUSION: Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.
BACKGROUND AND AIM: The aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection. METHODS: The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits. RESULTS: There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001). CONCLUSION: Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.
Authors: Peter Malfertheiner; Francis Megraud; Colm A O'Morain; John Atherton; Anthony T R Axon; Franco Bazzoli; Gian Franco Gensini; Javier P Gisbert; David Y Graham; Theodore Rokkas; Emad M El-Omar; Ernst J Kuipers Journal: Gut Date: 2012-05 Impact factor: 23.059
Authors: H Kashimura; K Suzuki; M Hassan; K Ikezawa; T Sawahata; T Watanabe; A Nakahara; H Mutoh; N Tanaka Journal: Aliment Pharmacol Ther Date: 1999-04 Impact factor: 8.171
Authors: William McClellan; Stephen L Aronoff; W Kline Bolton; Sally Hood; Daniel L Lorber; K Linda Tang; Thomas F Tse; Brian Wasserman; Marc Leiserowitz Journal: Curr Med Res Opin Date: 2004-09 Impact factor: 2.580
Authors: Simone Buerkli; Ndèye Fatou Ndiaye; Colin I Cercamondi; Isabelle Herter-Aeberli; Diego Moretti; Michael B Zimmermann Journal: Nutrients Date: 2019-09-04 Impact factor: 5.717
Authors: Wesam A Nasif; Abeer Shaker E Ali; Hiba S Alamodi; Abeer A Alrefai; Atheer A Alzubedi; Haneen S Almasoudi; Razan M Sulaimani; Alaa A Sulaiman; Aisha A Alharbi Journal: Saudi Med J Date: 2021-06 Impact factor: 1.422