Literature DB >> 26932269

Erratum to: 'Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs'.

Jodel D Pearson1, Jingxi Zhang1, Zuoqiao Wu1, Kayla D Thew1, Katelynn J Rowe1, Julinor T C Bacani2, Robert J Ingham3.   

Abstract

Entities:  

Year:  2016        PMID: 26932269      PMCID: PMC4772308          DOI: 10.1186/s12943-016-0499-1

Source DB:  PubMed          Journal:  Mol Cancer        ISSN: 1476-4598            Impact factor:   27.401


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Unfortunately, the original version of this article [1] contained an error. A figure was mislabelled. In Figs. 5c and d the Doxorubicin (Doxo) concentrations should be in μM. Here is most recent version of the figure with it correctly labelled. From: Expression of granzyme B sensitizes ALK + ALCL tumour cells to apoptosis-inducing drugs. GzB knock-down reduces the sensitivity of ALK + ALCL cell lines to doxorubicin-induced apoptosis. SUP-M2 (a) or SR (b) cells expressing either control or GzB targeting shRNA were left untreated (untr.) or were treated with indicated concentrations of doxorubicin (Doxo) for 12 h at 37 °C. Cells were then lysed and lysates were probed with an anti-PARP antibody. The arrow indicates cleaved PARP. The anti-β-actin blot demonstrates equivalent protein loading. The percent cleaved PARP (% cleaved PARP) was determined by densitometry and represents the percentage of cleaved PARP as a fraction of total PARP. Molecular mass standards are indicated to the left of the western blots. SUP-M2 (c) or SR (d) cells expressing either control or GzB shRNA were left untreated (DMSO) or were treated with the indicated concentrations of doxorubicin (doxo) for 12 h at 37 °C. DNA fragmentation was then examined by TUNEL staining and results were expressed as the percentage of TUNEL-positive cells. The results shown represent the mean and standard deviation of 4 independent experiments. p values comparing cells expressing GzB shRNA to cells expressing control shRNA were obtained by performing paired, one-tailed t-tests. *p < 0.05, §p < 0.01, #p < 0.005, δp < 0.001
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1.  Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs.

Authors:  Joel D Pearson; Jingxi Zhang; Zuoqiao Wu; Kayla D Thew; Katelynn J Rowe; Julinor T C Bacani; Robert J Ingham
Journal:  Mol Cancer       Date:  2014-08-29       Impact factor: 27.401

  1 in total

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