Vicki S Conn1, Maithe Enriquez2, Todd M Ruppar2, Keith C Chan2. 1. University of Missouri School of Nursing, Columbia, MO, USA conn@missouri.edu. 2. University of Missouri School of Nursing, Columbia, MO, USA.
Abstract
OBJECTIVE: This systematic review applied meta-analytic procedures to integrate primary research that examined theory- or model-linked medication adherence interventions. METHODS: Extensive literature searching strategies were used to locate trials testing interventions with medication adherence behavior outcomes measured by electronic event monitoring, pharmacy refills, pill counts, and self-reports. Random-effects model analysis was used to calculate standardized mean difference effect sizes for medication adherence outcomes. RESULTS: Codable data were extracted from 146 comparisons with 19,348 participants. The most common theories and models were social cognitive theory and motivational interviewing. The overall weighted effect size for all interventions comparing treatment and control participants was 0.294. The effect size for interventions based on single-theories was 0.323 and for multiple-theory interventions was 0.214. Effect sizes for individual theories and models ranged from 0.041 to 0.447. The largest effect sizes were for interventions based on the health belief model (0.477) and adult learning theory (0.443). The smallest effect sizes were for interventions based on PRECEDE (0.041) and self-regulation (0.118). CONCLUSION: These findings suggest that theory- and model-linked interventions have a significant but modest effect on medication adherence outcomes.
OBJECTIVE: This systematic review applied meta-analytic procedures to integrate primary research that examined theory- or model-linked medication adherence interventions. METHODS: Extensive literature searching strategies were used to locate trials testing interventions with medication adherence behavior outcomes measured by electronic event monitoring, pharmacy refills, pill counts, and self-reports. Random-effects model analysis was used to calculate standardized mean difference effect sizes for medication adherence outcomes. RESULTS: Codable data were extracted from 146 comparisons with 19,348 participants. The most common theories and models were social cognitive theory and motivational interviewing. The overall weighted effect size for all interventions comparing treatment and control participants was 0.294. The effect size for interventions based on single-theories was 0.323 and for multiple-theory interventions was 0.214. Effect sizes for individual theories and models ranged from 0.041 to 0.447. The largest effect sizes were for interventions based on the health belief model (0.477) and adult learning theory (0.443). The smallest effect sizes were for interventions based on PRECEDE (0.041) and self-regulation (0.118). CONCLUSION: These findings suggest that theory- and model-linked interventions have a significant but modest effect on medication adherence outcomes.
Authors: Robby Nieuwlaat; Nancy Wilczynski; Tamara Navarro; Nicholas Hobson; Rebecca Jeffery; Arun Keepanasseril; Thomas Agoritsas; Niraj Mistry; Alfonso Iorio; Susan Jack; Bhairavi Sivaramalingam; Emma Iserman; Reem A Mustafa; Dawn Jedraszewski; Chris Cotoi; R Brian Haynes Journal: Cochrane Database Syst Rev Date: 2014-11-20
Authors: Sarah D Fenerty; Cameron West; Scott A Davis; Sebastian G Kaplan; Steven R Feldman Journal: Patient Prefer Adherence Date: 2012-02-10 Impact factor: 2.711
Authors: K Rivet Amico; M Mugavero; Marie A Krousel-Wood; Hayden B Bosworth; Jessica S Merlin Journal: J Gen Intern Med Date: 2018-02 Impact factor: 5.128
Authors: Shoshana M Rosenberg; Keith J Petrie; Annette L Stanton; Lan Ngo; Emma Finnerty; Ann H Partridge Journal: J Natl Cancer Inst Date: 2020-05-01 Impact factor: 13.506
Authors: Sarah E Woolf-King; Alan Z Sheinfil; Jeremy Ramos; Jacklyn D Foley; Dezarie Moskal; Madison Firkey; David Kellen; Stephen A Maisto Journal: Health Psychol Rev Date: 2020-08-20