| Literature DB >> 26931445 |
Christine M Pierce Campbell1, Raphael P Viscidi2, B Nelson Torres1, Hui-Yi Lin3, William Fulp3, Martha Abrahamsen1, Eduardo Lazcano-Ponce4, Luisa L Villa5, Aimée R Kreimer6, Anna R Giuliano1.
Abstract
The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval, .56-4.76).Entities:
Keywords: HPV16; antibodies; men; oral HPV; serology
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Year: 2016 PMID： 26931445 PMCID： PMC4907411 DOI： 10.1093/infdis/jiw083
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226