Literature DB >> 26931062

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications.

R K Boyapati1,2, A G Rossi1, J Satsangi2, G-T Ho1,2.   

Abstract

Endogenous damage-associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human diseases. The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this review, we use IBD as an archetypal common chronic inflammatory disease to focus on the conceptual and evidential importance of DAMPs in pathogenesis and why DAMPs represent an entirely new class of targets for clinical translation.

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Year:  2016        PMID： 26931062     DOI： 10.1038/mi.2016.14

Source DB:  PubMed          Journal:  Mucosal Immunol        ISSN： 1933-0219            Impact factor:   7.313


  255 in total

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10.  Paneth cells as a site of origin for intestinal inflammation.

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Journal:  Nature       Date:  2013-10-02       Impact factor: 49.962
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  48 in total

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5.  Association of cell free mitochondrial DNA and caspase-1 expression with disease severity and ARTs efficacy in HIV infection.

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Review 6.  Mitochondrial DNA in Sepsis.

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Review 8.  Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing.

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Review 10.  Biomarkers in Search of Precision Medicine in IBD.

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