Literature DB >> 2693090

Expression of a muscle-type alpha-actinin cDNA clone in non-muscle cells.

P Jackson1, G Smith, D R Critchley.   

Abstract

We have previously isolated a chick smooth muscle-type alpha-actinin cDNA clone (C17) from a chick embryo fibroblast cDNA library. As part of an investigation into a possible role for a muscle isoform of alpha-actinin in non-muscle cells, we have cloned C17 into a eucaryotic expression vector, pKCR3, and examined the distribution of the expressed protein in non-muscle, monkey COS cells. We report here that the muscle isoform of chick alpha-actinin encoded by C17, was found in focal contacts and periodically distributed along actin filaments.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2693090

Source DB:  PubMed          Journal:  Eur J Cell Biol        ISSN： 0171-9335            Impact factor:   4.492


  5 in total

1.  A sarcomeric alpha-actinin truncated at the carboxyl end induces the breakdown of stress fibers in PtK2 cells and the formation of nemaline-like bodies and breakdown of myofibrils in myotubes.

Authors:  T Schultheiss; J Choi; Z X Lin; C DiLullo; L Cohen-Gould; D Fischman; H Holtzer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

2.  Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors.

Authors:  J J Krupp; B Vissel; C G Thomas; S F Heinemann; G L Westbrook
Journal:  J Neurosci       Date:  1999-02-15       Impact factor: 6.167

3.  Ligand binding to heparan sulfate proteoglycans induces their aggregation and distribution along actin cytoskeleton.

Authors:  R G Martinho; S Castel; J Ureña; M Fernández-Borja; R Makiya; G Olivecrona; M Reina; A Alonso; S Vilaró
Journal:  Mol Biol Cell       Date:  1996-11       Impact factor: 4.138

4.  Analysis of the actin-binding domain of alpha-actinin by mutagenesis and demonstration that dystrophin contains a functionally homologous domain.

Authors:  L Hemmings; P A Kuhlman; D R Critchley
Journal:  J Cell Biol       Date:  1992-03       Impact factor: 10.539

5.  The cytoskeletal protein talin contains at least two distinct vinculin binding domains.

Authors:  A P Gilmore; C Wood; V Ohanian; P Jackson; B Patel; D J Rees; R O Hynes; D R Critchley
Journal:  J Cell Biol       Date:  1993-07       Impact factor: 10.539
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.