AIMS: We systematically reviewed the role of low-level laser therapy (LLLT) in cardiac remodeling after myocardial infarction. MAIN METHODS: Literatures were systematically searched in several electronic databases. We included only studies with a well-standardized coronary occlusion model in vivo LLLT application. KEY FINDINGS: After screening, 14 studies were eligible for review. The study heterogeneity was described in terms of rationality, gender, irradiation parameters, treatment numbers and moment of LLLT application. Three studies showed a null role of LLLT on infarct size, and only one study found positive LLLT effects on the cardiac performance. The cardioprotective role of LLLT was mediated by anti-inflammatory, pro-angiogenic and anti-oxidant actions. SIGNIFICANCE: The reduction in infarct size is a major finding. The LLLT cardioprotection may be mediated by several molecular and cellular mechanisms. Although these results are exciting, there are many limitations that must be resolved before LLLT clinical trials.
AIMS: We systematically reviewed the role of low-level laser therapy (LLLT) in cardiac remodeling after myocardial infarction. MAIN METHODS: Literatures were systematically searched in several electronic databases. We included only studies with a well-standardized coronary occlusion model in vivo LLLT application. KEY FINDINGS: After screening, 14 studies were eligible for review. The study heterogeneity was described in terms of rationality, gender, irradiation parameters, treatment numbers and moment of LLLT application. Three studies showed a null role of LLLT on infarct size, and only one study found positive LLLT effects on the cardiac performance. The cardioprotective role of LLLT was mediated by anti-inflammatory, pro-angiogenic and anti-oxidant actions. SIGNIFICANCE: The reduction in infarct size is a major finding. The LLLT cardioprotection may be mediated by several molecular and cellular mechanisms. Although these results are exciting, there are many limitations that must be resolved before LLLT clinical trials.
Authors: Martha T Manchini; Ednei L Antônio; José Antônio Silva Junior; Paulo de Tarso C de Carvalho; Regiane Albertini; Fernando C Pereira; Regiane Feliciano; Jairo Montemor; Stella S Vieira; Vanessa Grandinetti; Amanda Yoshizaki; Marcio Chaves; Móises P da Silva; Rafael do Nascimento de Lima; Danilo S Bocalini; Bruno L de Melo; Paulo J F Tucci; Andrey J Serra Journal: Front Physiol Date: 2017-01-30 Impact factor: 4.566
Authors: Vanessa Grandinetti; Fernando Pereira Carlos; Ednei Luiz Antonio; Helenita Antonia de Oliveira; Luis Felipe Neves Dos Santos; Amanda Yoshizaki; Barbara Sampaio Dias Martins Mansano; Flávio André Silva; Leslie Andrews Porte; Gianna Móes Albuquerque-Pontes; Paulo de Tarso Camillo de Carvalho; Martha Trindade Manchini; Ernesto Cesar Leal-Junior; Paulo José Ferreira Tucci; Andrey Jorge Serra Journal: Sci Rep Date: 2019-07-01 Impact factor: 4.379