| Literature DB >> 26929053 |
Lynna Chen1, Harry Z An2, Ramin Haghgooie3, Aaron T Shank4, Joseph M Martel4, Mehmet Toner4, Patrick S Doyle2.
Abstract
Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell-capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.Entities:
Keywords: cell capture; circulating tumor cells; hydrogels; microfluidics; microparticles
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Year: 2016 PMID： 26929053 PMCID： PMC4903076 DOI： 10.1002/smll.201600163
Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281