Literature DB >> 26928847

The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification.

Jeffery M Tharp1, Wenshe R Liu2.   

Abstract

Pentelute and co-workers have identified a small encodable cysteine-containing peptide sequence that allows selective modification with perfluoroaryl probes. This π-clamp requires no external catalyst and is not limited to certain positions within a protein.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cysteine; pi clamp; protein modification; site selectivity

Mesh：

Substances：

Year:  2016        PMID： 26928847      PMCID： PMC4937881          DOI： 10.1002/cbic.201600106

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  9 in total

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Authors:  U Ilangovan; H Ton-That; J Iwahara; O Schneewind; R T Clubb
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2.  Occurrence, conformational features and amino acid propensities for the pi-helix.

Authors:  M N Fodje; Salam Al-Karadaghi
Journal:  Protein Eng       Date:  2002-05

Review 3.  Selective chemical protein modification.

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Authors:  Justin M Chalker; Gonçalo J L Bernardes; Yuya A Lin; Benjamin G Davis
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7.  Π-Clamp-mediated cysteine conjugation.

Authors:  Chi Zhang; Matthew Welborn; Tianyu Zhu; Nicole J Yang; Michael S Santos; Troy Van Voorhis; Bradley L Pentelute
Journal:  Nat Chem       Date:  2015-12-21       Impact factor: 24.427

8.  A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling.

Authors:  Alexander M Spokoyny; Yekui Zou; Jingjing J Ling; Hongtao Yu; Yu-Shan Lin; Bradley L Pentelute
Journal:  J Am Chem Soc       Date:  2013-04-16       Impact factor: 15.419

9.  Enzymatic "click" ligation: selective cysteine modification in polypeptides enabled by promiscuous glutathione S-transferase.

Authors:  Chi Zhang; Alexander M Spokoyny; Yekui Zou; Mark D Simon; Bradley L Pentelute
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-12       Impact factor: 15.336
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Journal:  Adv Drug Deliv Rev       Date:  2016-08-14       Impact factor: 15.470

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