Literature DB >> 26928631

Cross-generational transmission from drug abuse in parents to attention-deficit/hyperactivity disorder in children.

K S Kendler1, H Ohlsson2, K Sundquist2, J Sundquist2.   

Abstract

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) predisposes to drug abuse (DA) and twin studies suggest shared genetic effects. We here seek to determine, using adoption and adoption-like samples, the magnitude of the cross-generational transmission from DA in parents to ADHD in their children and clarify the degree to which this arises from genetic v. rearing effects.
METHOD: We ascertained ADHD and DA from multiple Swedish registries. Statistical analysis was performed by Cox and path models.
RESULTS: Risk for ADHD was significantly and similarly increased in the offspring of biological mothers and fathers with DA who did v. did not rear their offspring. Risk for ADHD was not elevated in the offspring of adoptive or step-parents with DA.
CONCLUSIONS: Cross-generational transmission was observed from DA in parents to ADHD in their children. An analysis of adoptive and adoptive-like parent-offspring relationships suggested that this transmission results from genetic and not from rearing effects.

Entities:  

Keywords:  Adoption; attention-deficit/hyperactivity disorder; drug abuse; parent-offspring transmission

Mesh：

Year:  2016        PMID： 26928631      PMCID： PMC4832920          DOI： 10.1017/S0033291715002846

Source DB:  PubMed          Journal:  Psychol Med        ISSN： 0033-2917            Impact factor:   7.723


  32 in total

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2.  The causes of parent-offspring transmission of drug abuse: a Swedish population-based study.

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7.  Within-family environmental transmission of drug abuse: a Swedish national study.

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Review 4.  Parental characteristics and offspring mental health and related outcomes: a systematic review of genetically informative literature.

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5.  Patterns of Psychiatric Comorbidity and Genetic Correlations Provide New Insights Into Differences Between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.

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6.  Parental substance use disorder and offspring not in education, employment or training: a national cohort study of young adults in Sweden.

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