| Literature DB >> 26928589 |
Cailing Ren1, Jie Qi2, Wanwei Li3, Jun Zhang2.
Abstract
The objective of this study was to observe the effects of moderate-intensity training on the activity of heme oxygenase (HO) and expression of HO-1 mRNA in the aorta and the cardiac muscle of spontaneously hypertensive rats (SHRs). After 9 weeks of swimming exercise, the activity of HO and expression of HO-1 mRNA in the SHRs were measured. The resting blood pressure in the exercise group was increased by 1.7% (P > 0.05), whereas it was significantly elevated by 10.3% (P < 0.01) in the SHR rats. Compared with animals in the control and sedentary groups, the expression level of HO-1 mRNA of aorta and cardiac muscle in the exercise group was significantly enhanced (P < 0.01). The HO activity and the content of plasma carbon monoxide (CO) in the sedentary group were dramatically decreased (P < 0.05 and P < 0.01, respectively) compared with the control group. HO activity and content of plasma CO in the exercise group were significantly higher compared with those in the sedentary group (P < 0.05 and P < 0.01, respectively). The HO/CO metabolic pathway might be involved in the regulation of blood pressure of the SHR models.Entities:
Keywords: HO activity; HO-1 mRNA expression; activité de l’HO; cardiac and vascular smooth muscle; entraînement physique; exercise; expression de l’ARNm du gène HO-1; muscles cardiaque et vasculaire lisse; rats spontanément hypertendus; spontaneously hypertensive rats
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Year: 2015 PMID： 26928589 DOI： 10.1139/cjpp-2015-0122
Source DB: PubMed Journal: Can J Physiol Pharmacol ISSN： 0008-4212 Impact factor: 2.273