Literature DB >> 26928541

Studying the regulation of endosomal cAMP production in GPCR signaling.

Alexandre Gidon1, Timothy N Feinstein2, Kunhong Xiao3, Jean-Pierre Vilardaga3.   

Abstract

We describe methods based on live cell fluorescent microscopy and mass spectrometry to characterize the mechanism of endosomal cAMP production and its regulation using the parathyroid hormone (PTH) type 1 receptor as a prime example. These methods permit to measure rapid changes of cAMP levels in response to PTH, kinetics of endosomal ligand-receptor interaction, pH changes associated with receptor trafficking, and to identify the endosomal receptor interactome.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Arrestin; Endosomal GPCR proteomics; Endosomal GPCR signaling; FRET; GPCR trafficking; PTH receptor; Receptor dynamics; TIRF

Mesh：

Substances：

Year:  2015        PMID： 26928541      PMCID： PMC4848751          DOI： 10.1016/bs.mcb.2015.10.007

Source DB:  PubMed          Journal:  Methods Cell Biol        ISSN： 0091-679X            Impact factor:   1.441


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