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Literature DB >> 2692849

Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2.

Abstract

Mutations in a known yeast gene, ADE3, were shown to act as an antisuppressor, reducing the efficiency of the omnipotent suppressor, sup45-2. The ADE3 locus encodes the trifunctional enzyme C1-tetrahydrofolate synthase, which is required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA(fMet. The role of this enzyme in translational fidelity had not previously been suspected.

Entities: Chemical Gene Species

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Year: 1989 PMID： 2692849 DOI： 10.1007/bf00340709

Source DB: PubMed Journal: Curr Genet ISSN： 0172-8083 Impact factor: 3.886

43 in total

1. Isolation and characterization of amber suppressors in yeast.

Authors: S W Liebman; F Sherman; J W Stewart
Journal: Genetics Date: 1976-02 Impact factor: 4.562

2. The allosuppressor gene SAL4 encodes a protein important for maintaining translational fidelity in Saccharomyces cerevisiae.

Authors: M Crouzet; F Izgu; C M Grant; M F Tuite
Journal: Curr Genet Date: 1988-12 Impact factor: 3.886

3. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.

Authors: M D Rose; P Novick; J H Thomas; D Botstein; G R Fink
Journal: Gene Date: 1987 Impact factor: 3.688

4. Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae.

Authors: K W Shannon; J C Rabinowitz
Journal: J Biol Chem Date: 1986-09-15 Impact factor: 5.157

5. A system for shotgun DNA sequencing.

Authors: J Messing; R Crea; P H Seeburg
Journal: Nucleic Acids Res Date: 1981-01-24 Impact factor: 16.971

6. Nucleotide sequence of the Saccharomyces cerevisiae ADE3 gene encoding C1-tetrahydrofolate synthase.

Authors: C Staben; J C Rabinowitz
Journal: J Biol Chem Date: 1986-04-05 Impact factor: 5.157

7. Isopentenyladenosine deficient tRNA from an antisuppressor mutant of Saccharomyces cerevisiae.

Authors: H Laten; J Gorman; R M Bock
Journal: Nucleic Acids Res Date: 1978-11 Impact factor: 16.971

8. Isolation of the SUP45 omnipotent suppressor gene of Saccharomyces cerevisiae and characterization of its gene product.

Authors: H J Himmelfarb; E Maicas; J D Friesen
Journal: Mol Cell Biol Date: 1985-04 Impact factor: 4.272

Mutations in ADE3 reduce the efficiency of the omnipotent suppressor sup45-2.

1. Isolation and characterization of amber suppressors in yeast.

2. The allosuppressor gene SAL4 encodes a protein important for maintaining translational fidelity in Saccharomyces cerevisiae.

3. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector.

4. Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae.

5. A system for shotgun DNA sequencing.

6. Nucleotide sequence of the Saccharomyces cerevisiae ADE3 gene encoding C1-tetrahydrofolate synthase.

7. Isopentenyladenosine deficient tRNA from an antisuppressor mutant of Saccharomyces cerevisiae.

8. Isolation of the SUP45 omnipotent suppressor gene of Saccharomyces cerevisiae and characterization of its gene product.

9. Genetic and biochemical characterization of antisuppressor mutants in the yeast Saccharomyces cerevisiae.

10. A general upstream binding factor for genes of the yeast translational apparatus.

1. Function of yeast cytoplasmic C1-tetrahydrofolate synthase.

2. Nonsense suppression in thymine-requiring strains of Escherichia coli is a consequence of altered folate metabolism.