S E Quirk1, A L Stuart2, S L Brennan-Olsen3, J A Pasco4, M Berk5, A M Chanen6, H Koivumaa-Honkanen7, M A Kotowicz8, P S Lukkala9, L J Williams2. 1. Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia. Electronic address: shae.quirk@barwonhealth.org.au. 2. Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia. 3. Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia; Institute of Health and Ageing, Australian Catholic University, Melbourne, Australia. 4. Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia; Melbourne Medical School-Western Campus, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Melbourne, Australia. 5. Department of Psychiatry, University of Melbourne, Melbourne, Australia; Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia & Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia; Barwon Health and the Geelong Clinic, Swanston Centre, Geelong, Australia; Florey Institute for Neuroscience and Mental Health, Melbourne, Melbourne, Australia. 6. Orygen, the National Centre of Excellence in Youth Mental Health, Melbourne, Australia & Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia. 7. Institute of Clinical Medicine, Psychiatry, University of Eastern Finland (UEF), Kuopio, Finland; Departments of Psychiatry, Kuopio University Hospital, Kuopio; South-Savonia Hospital District, Mikkeli; North Karelia Central Hospital, Joensuu; SOSTERI, Savonlinna; SOTE, Iisalmi; Lapland Hospital District, Rovaniemi, Finland; Clinic of Child Psychiatry, University Hospital of Oulu, Oulu, Finland. 8. Melbourne Medical School-Western Campus, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Melbourne, Australia; School of Medicine, Deakin University, Geelong, Australia. 9. School of Medicine, Faculty of Health Sciences, UEF, Kuopio, Finland; Bone and Cartilage Research Unit, Surgery, Institute of Clinical Medicine, UEF, Kuopio, Finland.
Abstract
BACKGROUND: Associations between common psychiatric disorders, psychotic disorders and physical health comorbidities are frequently investigated. The complex relationship between personality disorders (PDs) and physical health is less understood, and findings to date are varied. This study aims to investigate associations between PDs with a number of prevalent physical health conditions. METHODS: This study examined data collected from women (n=765;≥ 25 years) participating in a population-based study located in south-eastern Australia. Lifetime history of psychiatric disorders was assessed using the semi-structured clinical interviews (SCID-I/NP and SCID-II). The presence of physical health conditions (lifetime) were identified via a combination of self-report, medical records, medication use and clinical data. Socioeconomic status, and information regarding medication use, lifestyle behaviors, and sociodemographic information was collected via questionnaires. Logistic regression models were used to investigate associations. RESULTS: After adjustment for sociodemographic variables (age, socioeconomic status) and health-related factors (body mass index, physical activity, smoking, psychotropic medication use), PDs were consistently associated with a range of physical health conditions. Novel associations were observed between Cluster A PDs and gastro-oesophageal reflux disease (GORD); Cluster B PDs with syncope and seizures, as well as arthritis; and Cluster C PDs with GORD and recurrent headaches. CONCLUSIONS: PDs were associated with physical comorbidity. The current data contribute to a growing evidence base demonstrating associations between PDs and a number of physical health conditions independent of psychiatric comorbidity, sociodemographic and lifestyle factors. Longitudinal studies are now required to investigate causal pathways, as are studies determining pathological mechanisms.
BACKGROUND: Associations between common psychiatric disorders, psychotic disorders and physical health comorbidities are frequently investigated. The complex relationship between personality disorders (PDs) and physical health is less understood, and findings to date are varied. This study aims to investigate associations between PDs with a number of prevalent physical health conditions. METHODS: This study examined data collected from women (n=765;≥ 25 years) participating in a population-based study located in south-eastern Australia. Lifetime history of psychiatric disorders was assessed using the semi-structured clinical interviews (SCID-I/NP and SCID-II). The presence of physical health conditions (lifetime) were identified via a combination of self-report, medical records, medication use and clinical data. Socioeconomic status, and information regarding medication use, lifestyle behaviors, and sociodemographic information was collected via questionnaires. Logistic regression models were used to investigate associations. RESULTS: After adjustment for sociodemographic variables (age, socioeconomic status) and health-related factors (body mass index, physical activity, smoking, psychotropic medication use), PDs were consistently associated with a range of physical health conditions. Novel associations were observed between Cluster A PDs and gastro-oesophageal reflux disease (GORD); Cluster B PDs with syncope and seizures, as well as arthritis; and Cluster C PDs with GORD and recurrent headaches. CONCLUSIONS: PDs were associated with physical comorbidity. The current data contribute to a growing evidence base demonstrating associations between PDs and a number of physical health conditions independent of psychiatric comorbidity, sociodemographic and lifestyle factors. Longitudinal studies are now required to investigate causal pathways, as are studies determining pathological mechanisms.
Authors: Mirra R Seigerman; Jennifer K Betts; Carol Hulbert; Ben McKechnie; Victoria K Rayner; Martina Jovev; Sue M Cotton; Louise McCutcheon; Catharine McNab; Emma Burke; Andrew M Chanen Journal: Borderline Personal Disord Emot Dysregul Date: 2020-07-22