Marisol Carrillo-Solano1, Smaranda Leu-Semenescu2, Jean-Louis Golmard3, Elisabeth Groos1, Isabelle Arnulf4. 1. Sleep Disorders Unit of the Pitié-Salpêtrière University Hospital, APHP, Paris, France. 2. Sleep Disorders Unit of the Pitié-Salpêtrière University Hospital, APHP, Paris, France; Biostatistics Department of the Pitié-Salpêtrière University Hospital, APHP, Paris, France. 3. Sorbonne University, UPMC Univ Paris 06, IHU Neuroscience, Paris, France. 4. Sleep Disorders Unit of the Pitié-Salpêtrière University Hospital, APHP, Paris, France; Biostatistics Department of the Pitié-Salpêtrière University Hospital, APHP, Paris, France; Brain Research Institute (CRICM), INSERM UMR-S975, CNRS UMR7225, Paris, France. Electronic address: isabelle.arnulf@psl.aphp.fr.
Abstract
OBJECTIVE: To identify the determinants of excessive daytime sleepiness in adults with sleepwalking or sleep terrors (SW/ST). METHODS: We collected the charts of all consecutive adult patients admitted from 2012 to 2014 for SW/ST. They had completed the Paris Arousal Disorders Severity Scale and the Epworth Sleepiness Scale, and had undergone one (n = 34) or two consecutive (n = 124) nocturnal videopolysomnographies. The demographic, clinical, and sleep determinants of excessive daytime sleepiness (defined as an Epworth Sleepiness Scale score of greater than 10) were analyzed. RESULTS: Almost half (46.8%) of the 158 adult patients with SW/ST reported excessive daytime sleepiness. They had shorter sleep onset latencies (in night 1 and night 2), shorter REM sleep latencies, longer total sleep time, and higher REM sleep percentages in night 2, but no greater clinical severity of the parasomnia than patients without sleepiness. The level of sleepiness correlated with the same measures (sleep onset latency on both nights, REM sleep onset latency, and total sleep time in night 2), plus the latency to N3. In the regression model, higher sleepiness was determined by shorter sleep onset latency on night 1, lower number of awakenings in N3 on night 1, and higher total sleep time on night 2. CONCLUSION: Daytime sleepiness in patients with SW/ST is not the consequence of disturbed sleep but is associated with a specific polygraphic phenotype (rapid sleep onset, long sleep time, lower numbers of awakenings on N3) that is suggestive of a higher sleep pressure that may contribute to incomplete arousal from N3.
OBJECTIVE: To identify the determinants of excessive daytime sleepiness in adults with sleepwalking or sleep terrors (SW/ST). METHODS: We collected the charts of all consecutive adult patients admitted from 2012 to 2014 for SW/ST. They had completed the Paris Arousal Disorders Severity Scale and the Epworth Sleepiness Scale, and had undergone one (n = 34) or two consecutive (n = 124) nocturnal videopolysomnographies. The demographic, clinical, and sleep determinants of excessive daytime sleepiness (defined as an Epworth Sleepiness Scale score of greater than 10) were analyzed. RESULTS: Almost half (46.8%) of the 158 adult patients with SW/ST reported excessive daytime sleepiness. They had shorter sleep onset latencies (in night 1 and night 2), shorter REM sleep latencies, longer total sleep time, and higher REM sleep percentages in night 2, but no greater clinical severity of the parasomnia than patients without sleepiness. The level of sleepiness correlated with the same measures (sleep onset latency on both nights, REM sleep onset latency, and total sleep time in night 2), plus the latency to N3. In the regression model, higher sleepiness was determined by shorter sleep onset latency on night 1, lower number of awakenings in N3 on night 1, and higher total sleep time on night 2. CONCLUSION: Daytime sleepiness in patients with SW/ST is not the consequence of disturbed sleep but is associated with a specific polygraphic phenotype (rapid sleep onset, long sleep time, lower numbers of awakenings on N3) that is suggestive of a higher sleep pressure that may contribute to incomplete arousal from N3.
Authors: Petra van Mierlo; Lieke W A Hermans; Isabelle Arnulf; Angelique Pijpers; Sebastiaan Overeem; Merel M van Gilst Journal: J Clin Sleep Med Date: 2022-04-01 Impact factor: 4.062