Literature DB >> 26927426

Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents.

Dnyaneshwar D Subhedar1, Mubarak H Shaikh1, Manisha A Arkile2, Amar Yeware2, Dhiman Sarkar2, Bapurao B Shingate3.   

Abstract

We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antitubercular; Cytotoxicity; Green protocol; Multicomponent reaction

Mesh：

Substances：

Year:  2016        PMID： 26927426     DOI： 10.1016/j.bmcl.2016.02.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Ionic Liquid-Catalyzed Green Protocol for Multi-Component Synthesis of Dihydropyrano[2,3-c]pyrazoles as Potential Anticancer Scaffolds.

Authors:  Urja D Nimbalkar; Julio A Seijas; Maria Pilar Vazquez-Tato; Manoj G Damale; Jaiprakash N Sangshetti; Anna Pratima G Nikalje
Journal:  Molecules       Date:  2017-09-28       Impact factor: 4.411

2.  Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) tethered to nano-Fe3O4 as a superior catalyst for the synthesis of 1,3-thiazoles.

Authors:  Hossein Shahbazi-Alavi; Sheida Khojasteh-Khosro; Javad Safaei-Ghomi; Maryam Tavazo
Journal:  BMC Chem       Date:  2019-10-12

3.  One-Pot Synthesis of Novel 2-Imino-5-Arylidine-Thiazolidine Analogues and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line.

Authors:  Marian N Aziz; Arzoo Patel; Amany Iskander; Avisankar Chini; Delphine Gout; Subhrangsu S Mandal; Carl J Lovely
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411

4.  New N-phenylacetamide-incorporated 1,2,3-triazoles: [Et3NH][OAc]-mediated efficient synthesis and biological evaluation.

Authors:  Satish V Akolkar; Amol A Nagargoje; Vagolu S Krishna; Dharmarajan Sriram; Jaiprakash N Sangshetti; Manoj Damale; Bapurao B Shingate
Journal:  RSC Adv       Date:  2019-07-18       Impact factor: 4.036

5.  Synthesis of novel inhibitors of α-amylase based on the thiazolidine-4-one skeleton containing a pyrazole moiety and their configurational studies.

Authors:  Parvin Kumar; Meenakshi Duhan; Kulbir Kadyan; Jayant Sindhu; Sunil Kumar; Hitender Sharma
Journal:  Medchemcomm       Date:  2017-05-16       Impact factor: 3.597

6.  Triazole-diindolylmethane conjugates as new antitubercular agents: synthesis, bioevaluation, and molecular docking.

Authors:  Ashruba B Danne; Amit S Choudhari; Shakti Chakraborty; Dhiman Sarkar; Vijay M Khedkar; Bapurao B Shingate
Journal:  Medchemcomm       Date:  2018-04-11       Impact factor: 3.597

7.  Synthesis of functionalized imidazo[4,5-e]thiazolo[3,2-b]triazines by condensation of imidazo[4,5-e]triazinethiones with DMAD or DEAD and rearrangement to imidazo[4,5-e]thiazolo[2,3-c]triazines.

Authors:  Alexei N Izmest'ev; Dmitry B Vinogradov; Natalya G Kolotyrkina; Angelina N Kravchenko; Galina A Gazieva
Journal:  Beilstein J Org Chem       Date:  2021-05-14       Impact factor: 2.883

Review 8.  Saturated Five-Membered Thiazolidines and Their Derivatives: From Synthesis to Biological Applications.

Authors:  Nusrat Sahiba; Ayushi Sethiya; Jay Soni; Dinesh K Agarwal; Shikha Agarwal
Journal:  Top Curr Chem (Cham)       Date:  2020-03-23
  8 in total

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