| Literature DB >> 26927205 |
Lucia Mori1,2, Marco Lepore1, Gennaro De Libero1,2.
Abstract
CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response, orchestrating the function of other cells. This review addresses the main aspects of their immunological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic antigen presentation, and the current evidence for their participation in human and experimental diseases.Entities:
Keywords: T cell receptor; antigen presentation; autoimmune diseases; infectious diseases; innate-like T cells; lipid antigens; metabolite antigens; mucosal-associated invariant T cells; natural killer T cells; tumor immunity
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Year: 2016 PMID： 26927205 DOI： 10.1146/annurev-immunol-032414-112008
Source DB: PubMed Journal: Annu Rev Immunol ISSN： 0732-0582 Impact factor: 28.527