Joe Saliba1, Naif Fnais1,2, Marcel Tomaszewski1, Junie S Carriere3, Saul Frenkiel1, Johannes Frasnelli4,5, Marc A Tewfik1. 1. Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada. 2. Department of Otolaryngology-Head and Neck Surgery, King Saud University, Riyadh, Saudi Arabia. 3. Department of Psychology, McGill University, Montreal, Quebec, Canada. 4. Research Chair for Chemosensory Neuroanatomy, Department of Anatomy, University of Quebec in Trois-Rivières, Trois-Rivières, Quebec, Canada. 5. Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital, Montreal, Quebec, Canada.
Abstract
OBJECTIVES/HYPOTHESIS: Trigeminal sensation (TS) within the nasal cavity is important for the perception of nasal airflow. The objective of this study is to examine whether impaired TS contributes to the sensation of nasal obstruction in patients with chronic rhinosinusitis (CRS). STUDY DESIGN: Prospective case-control study conducted in a tertiary referral rhinology clinic. METHODS: Cases consisted of CRS patients with subjective nasal obstruction, not previously treated with oral corticoids. Controls consisted of patients without CRS. Neither group demonstrated obvious anatomical obstructions. Both groups underwent peak nasal inspiratory flows (PNIF), olfactory testing (quick eight-item odor identification test), and trigeminal testing (lateralization task using eucalyptol and odorless solvent). RESULTS: A total of 28 subjects (14 CRS patients and 14 controls) were recruited. Analyses revealed no statistical differences in age (P = .93), gender (P = .47), or PNIF (P = .82) between the two groups, but they differed in Lund-Mackay scores (P < .001). There was no significant difference in olfactory testing (P = .15). CRS patients had significantly lower scores on trigeminal lateralization testing than controls (P = .007). Linear regression revealed that Lund-Mackay scores contributed a significant amount of variance to trigeminal lateralization scores, controlling for age and sex (F = 5.93, P = .004, R(2) = 0.43). CONCLUSIONS: This is the first study to demonstrate that patients with CRS have lower TS than healthy controls. Our results suggest defective TS could play a role in the sensation of nasal obstruction in CRS. LEVEL OF EVIDENCE: 3b. Laryngoscope, 126:E174-E178, 2016.
OBJECTIVES/HYPOTHESIS: Trigeminal sensation (TS) within the nasal cavity is important for the perception of nasal airflow. The objective of this study is to examine whether impaired TS contributes to the sensation of nasal obstruction in patients with chronic rhinosinusitis (CRS). STUDY DESIGN: Prospective case-control study conducted in a tertiary referral rhinology clinic. METHODS: Cases consisted of CRSpatients with subjective nasal obstruction, not previously treated with oral corticoids. Controls consisted of patients without CRS. Neither group demonstrated obvious anatomical obstructions. Both groups underwent peak nasal inspiratory flows (PNIF), olfactory testing (quick eight-item odor identification test), and trigeminal testing (lateralization task using eucalyptol and odorless solvent). RESULTS: A total of 28 subjects (14 CRSpatients and 14 controls) were recruited. Analyses revealed no statistical differences in age (P = .93), gender (P = .47), or PNIF (P = .82) between the two groups, but they differed in Lund-Mackay scores (P < .001). There was no significant difference in olfactory testing (P = .15). CRSpatients had significantly lower scores on trigeminal lateralization testing than controls (P = .007). Linear regression revealed that Lund-Mackay scores contributed a significant amount of variance to trigeminal lateralization scores, controlling for age and sex (F = 5.93, P = .004, R(2) = 0.43). CONCLUSIONS: This is the first study to demonstrate that patients with CRS have lower TS than healthy controls. Our results suggest defective TS could play a role in the sensation of nasal obstruction in CRS. LEVEL OF EVIDENCE: 3b. Laryngoscope, 126:E174-E178, 2016.
Authors: Chengyu Li; Alexander A Farag; Guillermo Maza; Sam McGhee; Michael A Ciccone; Bhakthi Deshpande; Edmund A Pribitkin; Bradley A Otto; Kai Zhao Journal: Int Forum Allergy Rhinol Date: 2017-11-22 Impact factor: 3.858
Authors: Hung-Jui Hsu; Chia-Yi Lee; Kun-Lin Yang; Hung-Chi Chen; Chi-Chin Sun; Jing-Yang Huang; Hung-Yu Lin; Shun-Fa Yang Journal: Int J Environ Res Public Health Date: 2019-04-05 Impact factor: 3.390