Colleen Peyton1, Edward Yang2, Masha Kocherginsky3, Lars Adde4, Toril Fjørtoft4, Ragnhild Støen5, Arend F Bos6, Christa Einspieler7, Michael D Schreiber2, Michael E Msall2. 1. Department of Therapy Services, University of Chicago Medicine, 5841 S. Maryland Ave, Chicago, IL 60637, USA. Electronic address: colleen.peyton@uchospitals.edu. 2. Department of Pediatrics, University of Chicago Medicine, Comer Children's Hospital, Sections of Neonatology, Developmental Pediatrics, 5841 S. Maryland Ave, Chicago, IL 60637, USA; Kennedy Research Center on Intellectual and Neurodevelopmental Disabilities, 5841 S. Maryland Ave, Chicago, IL 60637, USA. 3. Department of Health Studies, University of Chicago Medicine, 5841 S. Maryland Ave, Chicago, IL 60637, USA. 4. Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Olav Kyrres gt. 11, 7491 Trondheim, Norway; Clinics of Clinical Services, St. Olav University Hospital, Box 3250, Sluppen, 7006 Trondheim, Norway. 5. Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Olav Kyrres gt. 11, 7491 Trondheim, Norway; Department of Pediatrics, St. Olav University Hospital, Box 3250, Sluppen, 7006 Trondheim, Norway. 6. Division of Neonatology, University of Groningen, 9712 CP Groningen, Netherlands. 7. Institute of Physiology, Center for Physiological Medicine, Medical University of Graz, Universitätsstraße 15, 8010 Graz, Austria.
Abstract
BACKGROUND: Cerebral Magnetic Resonance Imaging, the General Movement Assessment, and the Test of Infant Motor Performance are all tools that can predict neurodevelopmental outcome in preterm infants. However, how these tests relate to each other is unclear. AIMS: To examine the relationship between cerebral Magnetic Resonance Imaging measured at term age, and the General Movement Assessment and Test of Infant Motor Performance measured at 10-15 weeks post-term age. STUDY DESIGN: Prospectively collected data in a sample of very preterm infants. SUBJECTS: Fifty-three infants (23 female, 30 male) with a median gestational age of 28 weeks (range: 23-30 weeks) and a median birth weight of 1000 g (range: 515-1465 g). OUTCOME MEASURES: Test of Infant Motor Performance, General Movement Assessment. RESULTS: Infants with abnormal white matter were significantly more likely to have both abnormal general movements (p=0.01) and abnormal Test of Infant Motor Performance scores (p=0.001). Infants with abnormal general movements were significantly more likely to have lower Test of Infant Motor Performance Scores (p=0.01). CONCLUSIONS: Abnormal white matter is related to motor deviations as measured by the General Movement Assessment and the Test of Infant Motor Performance as early as 3 months post-term age in a cohort of preterm infants.
BACKGROUND: Cerebral Magnetic Resonance Imaging, the General Movement Assessment, and the Test of Infant Motor Performance are all tools that can predict neurodevelopmental outcome in preterm infants. However, how these tests relate to each other is unclear. AIMS: To examine the relationship between cerebral Magnetic Resonance Imaging measured at term age, and the General Movement Assessment and Test of Infant Motor Performance measured at 10-15 weeks post-term age. STUDY DESIGN: Prospectively collected data in a sample of very preterm infants. SUBJECTS: Fifty-three infants (23 female, 30 male) with a median gestational age of 28 weeks (range: 23-30 weeks) and a median birth weight of 1000 g (range: 515-1465 g). OUTCOME MEASURES: Test of Infant Motor Performance, General Movement Assessment. RESULTS:Infants with abnormal white matter were significantly more likely to have both abnormal general movements (p=0.01) and abnormal Test of Infant Motor Performance scores (p=0.001). Infants with abnormal general movements were significantly more likely to have lower Test of Infant Motor Performance Scores (p=0.01). CONCLUSIONS:Abnormal white matter is related to motor deviations as measured by the General Movement Assessment and the Test of Infant Motor Performance as early as 3 months post-term age in a cohort of preterm infants.
Authors: J M George; S Fiori; J Fripp; K Pannek; J Bursle; R X Moldrich; A Guzzetta; A Coulthard; R S Ware; S E Rose; P B Colditz; R N Boyd Journal: AJNR Am J Neuroradiol Date: 2017-05-18 Impact factor: 3.825
Authors: Erik van Tilborg; E J Marijke Achterberg; Caren M van Kammen; Annette van der Toorn; Floris Groenendaal; Rick M Dijkhuizen; Cobi J Heijnen; Louk J M J Vanderschuren; Manon N J L Benders; Cora H A Nijboer Journal: Glia Date: 2017-09-19 Impact factor: 7.452