Encapsulation of coagulase-negative staphylococci.

It is becoming clear that encapsulation is frequent among coagulase negative staphylococci and is unrelated to the formation of extracellular polysaccharide slime by many strains. Crude slime may contain capsular polysaccharides or proteins, as well as cell wall components, but this is probably the result of cell wall turnover in growing bacteria. As in coagulase-positive staphylococci the capsules confer resistance to phagocytosis and can be regarded as important virulence factors. The observation that within the species S. epidermidis several different capsular types can be distinguished serologically suggests the possibility of using the presence and serotype of capsule for biotyping. There is a great need for detailed structural studies of capsular polysaccharides and for the investigation of the role of proteins in the capsules. Several published analyses fail to account for substantial proportions of the weight of isolated capsular material, indicating the presence of components yet to be recognised. Preliminary studies have revealed interesting biological activities of capsular components in humans and experimental animals and further work is likely to provide important new information about the pathogenesis of opportunistic infections by this group of bacteria.