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Literature DB >> 26924734

4-amino-7-chloroquinoline derivatives for treating Parkinson's disease: implications for drug discovery.

Chun-Hyung Kim^1,2, Pierre Leblanc¹, Kwang-Soo Kim¹.

Abstract

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2016 PMID： 26924734 PMCID： PMC4810450 DOI： 10.1517/17460441.2016.1154529

Source DB: PubMed Journal: Expert Opin Drug Discov ISSN： 1746-0441 Impact factor: 6.098

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35 in total

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2. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells.

Authors: Xi Li; Syng-Ook Lee; Stephen Safe
Journal: Biochem Pharmacol Date: 2012-03-03 Impact factor: 5.858

3. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB.

Authors: Briana R De Miranda; Katriana A Popichak; Sean L Hammond; Bryce A Jorgensen; Aaron T Phillips; Stephen Safe; Ronald B Tjalkens
Journal: Mol Pharmacol Date: 2015-04-09 Impact factor: 4.436

4. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

Authors: Briana R De Miranda; Katriana A Popichak; Sean L Hammond; James A Miller; Stephen Safe; Ronald B Tjalkens
Journal: Toxicol Sci Date: 2014-11-17 Impact factor: 4.849

5. Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease.

Authors: Zhen Zhang; Xuping Li; Wen-jie Xie; Houzhen Tuo; Samuel Hintermann; Joseph Jankovic; Weidong Le
Journal: CNS Neurol Disord Drug Targets Date: 2012-09 Impact factor: 4.388

6. miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression.

Authors: Dehua Yang; Ting Li; Yi Wang; Yuanjia Tang; Huijuan Cui; Yu Tang; Xiaojie Zhang; Degui Chen; Nan Shen; Weidong Le
Journal: J Cell Sci Date: 2012-02-10 Impact factor: 5.285

7. Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.

Authors: Banafsheh Kadkhodaei; Alexandra Alvarsson; Nicoletta Schintu; Daniel Ramsköld; Nikolaos Volakakis; Eliza Joodmardi; Takashi Yoshitake; Jan Kehr; Mickael Decressac; Anders Björklund; Rickard Sandberg; Per Svenningsson; Thomas Perlmann
Journal: Proc Natl Acad Sci U S A Date: 2013-01-22 Impact factor: 11.205

Review 8. Autophagy modulation as a potential therapeutic target for diverse diseases.

Authors: David C Rubinsztein; Patrice Codogno; Beth Levine
Journal: Nat Rev Drug Discov Date: 2012-09 Impact factor: 84.694

9. A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

Authors: Gaynor A Smith; Emily M Rocha; Thomas Rooney; Pascal Barneoud; Jesse R McLean; Jonathan Beagan; Teresia Osborn; Madeleine Coimbra; Yongyi Luo; Penelope J Hallett; Ole Isacson
Journal: PLoS One Date: 2015-03-27 Impact factor: 3.240

10. Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.

Authors: Francesca Montarolo; Chiara Raffaele; Simona Perga; Serena Martire; Annamaria Finardi; Roberto Furlan; Samuel Hintermann; Antonio Bertolotto
Journal: PLoS One Date: 2014-09-29 Impact factor: 3.240

8 in total

1. Toward neuroprotective treatments of Parkinson's disease.

Authors: Kwang-Soo Kim
Journal: Proc Natl Acad Sci U S A Date: 2017-03-30 Impact factor: 11.205

2. Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.

Authors: Stephan Chalon; M Farouk Chughlay; Nada Abla; Andre Marie Tchouatieu; Amina Haouala; Ben Hutter; Ulrike Lorch; Fiona Macintyre
Journal: Clin Pharmacol Ther Date: 2021-09-14 Impact factor: 6.903

Review 3. The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases.

Authors: Na Liu; Miao-Miao Lin; Yan Wang
Journal: Mol Neurobiol Date: 2022-10-19 Impact factor: 5.682

4. Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1.

Authors: Paola Munoz-Tello; Hua Lin; Pasha Khan; Ian Mitchelle S de Vera; Theodore M Kamenecka; Douglas J Kojetin
Journal: J Med Chem Date: 2020-12-08 Impact factor: 7.446

5. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function.

Authors: Sreekanth Rajan; Yongwoo Jang; Chun-Hyung Kim; Woori Kim; Hui Ting Toh; Jeha Jeon; Bin Song; Aida Serra; Julien Lescar; Jun Yeob Yoo; Serap Beldar; Hong Ye; Congbao Kang; Xue-Wei Liu; Melissa Feitosa; Yeahan Kim; Dabin Hwang; Geraldine Goh; Kah-Leong Lim; Hye Min Park; Choong Hwan Lee; Sungwhan F Oh; Gregory A Petsko; Ho Sup Yoon; Kwang-Soo Kim
Journal: Nat Chem Biol Date: 2020-05-25 Impact factor: 15.040