Literature DB >> 26924385

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases.

Mitchell Hattie1, Nevena Cekic2, Aleksandra W Debowski3, David J Vocadlo4, Keith A Stubbs1.   

Abstract

The synthesis of analogues of the potent N-acetylhexosaminidase inhibitor, PUGNAc, are described. These compounds were assayed against a set of biologically important N-acetyl-d-glucosaminidases and were found to vary in both potency and selectivity.

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Year:  2016        PMID： 26924385     DOI： 10.1039/c6ob00297h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  2 in total

1.  2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes.

Authors:  Mariann Kiss; István Timári; Teréz Barna; Zuzana Mészáros; Kristýna Slámová; Pavla Bojarová; Vladimír Křen; Joseph M Hayes; László Somsák
Journal:  Int J Mol Sci       Date:  2022-01-18       Impact factor: 5.923

2.  Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors.

Authors:  Shengqiang Shen; Wei Chen; Lili Dong; Qing Yang; Huizhe Lu; Jianjun Zhang
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  2 in total

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