Literature DB >> 26923718

Biological and pathological activities of interleukin-22.

Mirna Perusina Lanfranca1, Yanwei Lin1,2, Jingyuan Fang2, Weiping Zou3,4,5, Timothy Frankel6,7.   

Abstract

Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22(+)CD4(+) T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival, and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection, and malignancy. In this review, we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios and discuss the potential to target IL-22 signaling to treat human diseases.

Entities:  

Keywords:  Autoimmune; Cancer; IL-22; IL-22BP; IL-22R; ILC22; Infection; T cell; Th22

Mesh：

Substances：

Year:  2016        PMID： 26923718      PMCID： PMC4860114          DOI： 10.1007/s00109-016-1391-6

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  163 in total

1.  Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.

Authors:  S V Kotenko; L S Izotova; O V Mirochnitchenko; E Esterova; H Dickensheets; R P Donnelly; S Pestka
Journal:  J Biol Chem       Date:  2000-10-16       Impact factor: 5.157

2.  Requirement for RORgamma in thymocyte survival and lymphoid organ development.

Authors:  Z Sun; D Unutmaz; Y R Zou; M J Sunshine; A Pierani; S Brenner-Morton; R E Mebius; D R Littman
Journal:  Science       Date:  2000-06-30       Impact factor: 47.728

3.  Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9.

Authors:  L Dumoutier; J Louahed; J C Renauld
Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

4.  Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

Authors:  M H Xie; S Aggarwal; W H Ho; J Foster; Z Zhang; J Stinson; W I Wood; A D Goddard; A L Gurney
Journal:  J Biol Chem       Date:  2000-10-06       Impact factor: 5.157

5.  Acinar cells of the pancreas are a target of interleukin-22.

Authors:  S Aggarwal; M H Xie; M Maruoka; J Foster; A L Gurney
Journal:  J Interferon Cytokine Res       Date:  2001-12       Impact factor: 2.607

6.  IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes.

Authors:  L Dumoutier; E Van Roost; G Ameye; L Michaux; J C Renauld
Journal:  Genes Immun       Date:  2000-12       Impact factor: 2.676

7.  Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22.

Authors:  L Dumoutier; D Lejeune; D Colau; J C Renauld
Journal:  J Immunol       Date:  2001-06-15       Impact factor: 5.422

8.  Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity.

Authors:  S V Kotenko; L S Izotova; O V Mirochnitchenko; E Esterova; H Dickensheets; R P Donnelly; S Pestka
Journal:  J Immunol       Date:  2001-06-15       Impact factor: 5.422

9.  Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.

Authors:  L Dumoutier; E Van Roost; D Colau; J C Renauld
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205

10.  A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta.

Authors:  B H Gruenberg; A Schoenemeyer; B Weiss; L Toschi; S Kunz; K Wolk; K Asadullah; R Sabat
Journal:  Genes Immun       Date:  2001-10       Impact factor: 2.676
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  44 in total

1.  Targeting IL22: a potential therapeutic approach for Kras mutant lung cancer?

Authors:  Frank D Weinberg; Nithya Ramnath
Journal:  Transl Lung Cancer Res       Date:  2018-09

2.  Integrative strategy for improving cancer immunotherapy.

Authors:  Xuetao Cao
Journal:  J Mol Med (Berl)       Date:  2016-05       Impact factor: 4.599

3.  Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.

Authors:  Mirna Perusina Lanfranca; Yaqing Zhang; Alexander Girgis; Samantha Kasselman; Jenny Lazarus; Illona Kryczek; Lawrence Delrosario; Andrew Rhim; Lada Koneva; Maureen Sartor; Lei Sun; Christopher Halbrook; Hari Nathan; Jiaqi Shi; Howard C Crawford; Marina Pasca di Magliano; Weiping Zou; Timothy L Frankel
Journal:  Gastroenterology       Date:  2019-12-14       Impact factor: 22.682

Review 4.  Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy.

Authors:  Nisha Nagarsheth; Max S Wicha; Weiping Zou
Journal:  Nat Rev Immunol       Date:  2017-05-30       Impact factor: 53.106

5.  Induction of IL-22 protein and IL-22-producing cells in rainbow trout Oncorhynchus mykiss.

Authors:  Yehfang Hu; Yamila Carpio; Callum Scott; Ayham Alnabulsi; Abdo Alnabulsi; Tingyu Wang; Fuguo Liu; Milena Monte; Tiehui Wang; Christopher J Secombes
Journal:  Dev Comp Immunol       Date:  2019-07-12       Impact factor: 3.636

Review 6.  Reparative T lymphocytes in organ injury.

Authors:  Franco R D'Alessio; Johanna T Kurzhagen; Hamid Rabb
Journal:  J Clin Invest       Date:  2019-07-01       Impact factor: 14.808

7.  Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3.

Authors:  Huajun Han; Laurie A Davidson; Yang-Yi Fan; Kerstin K Landrock; Arul Jayaraman; Stephen H Safe; Robert S Chapkin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2021-11-10       Impact factor: 4.052

8.  P27 deletion enhances hematopoiesis by paracrine action of IL22 secreted from bone marrow mesenchymal stem cells.

Authors:  Ruinan Lu; Qian Wang; Jianyong Li; Dengshun Miao
Journal:  Am J Transl Res       Date:  2020-03-15       Impact factor: 4.060

9.  An immuno-blocking agent targeting IL-1β and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice.

Authors:  Qi Yin; Xuelei Pi; Yuanyuan Jiang; Guiping Ren; Zhihang Liu; Han Liu; Mengxia Wang; Wenying Sun; Siyu Li; Zhenqiu Gao; Deshan Li; Jiechao Yin
Journal:  Inflammation       Date:  2021-04-20       Impact factor: 4.092

Review 10.  Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development.

Authors:  Ailin Yang; Yanjun Wu; Ganggang Yu; Haoyan Wang
Journal:  Respir Res       Date:  2021-07-14
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