Literature DB >> 26923698

Poly-arginine conjugated triarylmethyl radical as intracellular spin label.

Benoit Driesschaert1, Andrey A Bobko1, Timothy D Eubank2, Alexandre Samouilov3, Valery V Khramtsov1, Jay L Zweier4.   

Abstract

Stable triarylmethyl radicals are ideal spin labels used for biomedical electron paramagnetic resonance applications. Previously reported structures exhibit polar charged functions for water solubilization preventing them from crossing the cell membrane. We report the synthesis of a triarylmethyl radical conjugated to poly-arginine peptide allowing intracellular delivery of the paramagnetic label.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cyclic voltammetry; EPR; Poly-arginine; Radical; TAM

Mesh：

Substances：

Year:  2016        PMID： 26923698      PMCID： PMC4807691          DOI： 10.1016/j.bmcl.2016.02.048

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

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9.  Synthesis of 14N- and 15N-labeled trityl-nitroxide biradicals with strong spin-spin interaction and improved sensitivity to redox status and oxygen.

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  4 in total

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2.  A combined positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) system: initial evaluation of a prototype scanner.

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3.  SLIM: A Short-Linked, Highly Redox-Stable Trityl Label for High-Sensitivity In-Cell EPR Distance Measurements.

Authors:  Nico Fleck; Caspar A Heubach; Tobias Hett; Florian R Haege; Pawel P Bawol; Helmut Baltruschat; Olav Schiemann
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4.  Synthesis of hydroxyethyl tetrathiatriarylmethyl radicals OX063 and OX071.

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  4 in total

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