Literature DB >> 26923696

Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity.

Toshio Kaneda1, Haruka Yoshida1, Yuki Nakajima1, Minako Toishi1, Alfarius Eko Nugroho1, Hiroshi Morita2.   

Abstract

Flaxseed (Linum usitatissimum seed) is widely used in food and natural health products. In our search for osteoclast differentiation inhibitors, some cyclic peptides isolated from flaxseed, known as the cyclolinopeptides, were discovered to have osteoclast differentiation inhibition activity. The osteoclast differentiation inhibition activity of cyclolinopeptides A-I (1-9) and their related derivatives (10-14) are described herein. Cyclolinopeptides F, H and I (6, 8 and 9), in particular, showed potent osteoclast differentiation inhibition activity.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cyclic peptides; Cyclolinopeptides; Flaxseed; Linum usitatissimum; Osteoclast differentiation

Mesh：

Substances：

Year:  2016        PMID： 26923696     DOI： 10.1016/j.bmcl.2016.02.040

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Cyclolinopeptide F, a cyclic peptide from flaxseed inhibited RANKL-induced osteoclastogenesis via downergulation of RANK expression.

Authors:  Toshio Kaneda; Yuki Nakajima; Sae Koshikawa; Alfarius Eko Nugroho; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-03-15       Impact factor: 2.343

2.  Identification and Characterization of the Stability of Hydrophobic Cyclolinopeptides From Flaxseed Oil.

Authors:  Adnan Fojnica; Hans-Jörg Leis; Michael Murkovic
Journal:  Front Nutr       Date:  2022-06-23

Review 3.  Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and Its Analogs in Animal Experimental Models.

Authors:  Michał Zimecki; Krzysztof Kaczmarek
Journal:  Molecules       Date:  2021-04-27       Impact factor: 4.411

4.  Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.

Authors:  Hee Jae Shin; Byeoung-Kyu Choi; Phan Thi Hoai Trinh; Hwa-Sun Lee; Jong Soon Kang; Tran Thi Thanh Van; Hyi-Seung Lee; Jong Seok Lee; Yeon-Ju Lee; Jihoon Lee
Journal:  Mar Drugs       Date:  2018-01-05       Impact factor: 5.118

5.  Purification and Characterization of a Novel Calcium-Binding Heptapeptide from the Hydrolysate of Tilapia Bone with Its Osteogenic Activity.

Authors:  Jinlun He; Hao Guo; Mei Zhang; Meng Wang; Liping Sun; Yongliang Zhuang
Journal:  Foods       Date:  2022-02-04

6.  Peptide Regulation of Gene Expression: A Systematic Review.

Authors:  Vladimir Khatskelevich Khavinson; Irina Grigor'evna Popovich; Natalia Sergeevna Linkova; Ekaterina Sergeevna Mironova; Anastasiia Romanovna Ilina
Journal:  Molecules       Date:  2021-11-22       Impact factor: 4.411

7.  Flaxseed orbitides, linusorbs, inhibit LPS-induced THP-1 macrophage inflammation.

Authors:  Xian-Guo Zou; Youn Young Shim; Jae Youl Cho; Deok Jeong; Jian Yang; Ze-Yuan Deng; Martin J T Reaney
Journal:  RSC Adv       Date:  2020-06-15       Impact factor: 4.036

8.  Activation Spectra of Human Bitter Taste Receptors Stimulated with Cyclolinopeptides Corresponding to Fresh and Aged Linseed Oil.

Authors:  Tatjana Lang; Oliver Frank; Roman Lang; Thomas Hofmann; Maik Behrens
Journal:  J Agric Food Chem       Date:  2022-04-01       Impact factor: 5.895

Review 9.  Bioprocessing of Functional Ingredients from Flaxseed.

Authors:  Christian Kwesi Ofotsu Dzuvor; Jordan Tauai Taylor; Caleb Acquah; Sharadwata Pan; Dominic Agyei
Journal:  Molecules       Date:  2018-09-24       Impact factor: 4.411
  9 in total

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