Yoo Hyun Um1, Jong-Hyun Jeong2, Seung-Chul Hong1, Tae-Won Kim1, Hyun Kook Lim1, Ho-Jun Seo1, Jin-Hee Han1. 1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 2. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: anton3@catholic.ac.kr.
Abstract
OBJECTIVE: Sleep problems are common among patients with attention-deficit hyperactivity disorder (ADHD), and are considered major causes of behavioral and cognitive dysfunction in ADHD patients. In the present study, we investigated the relationship between sleep parameters and cognitive function in drug-naïve children with ADHD. METHODS: Twenty-eight patients were recruited to participate in the study, and a polysomnography was used to measure sleep parameters of the subjects. Cognitive measurements were collected, utilizing the Wechsler Intelligence Scale for Children-III (WISC-III), and the Matching Familiar Figure Test for Korean Children (MFFT-KC), while behavioral characteristics of the subjects were assessed using Conners' Global Index-Parent version (CGI-P). Descriptive statistics were calculated for demographic data, sleep parameters, and neurocognitive characteristics of ADHD patients. Spearman's correlation analyses were performed to determine the association between sleep parameters and neurocognitive measures. Moreover, multiple regression analyses were used to identify the best predictors of cognitive function among the various sleep parameters. RESULTS: The regression analyses revealed several meaningful correlations, suggesting that slow wave sleep, stage 2 sleep, REM sleep, and limb movement index with arousals (LMAs) as predictors of cognitive function in ADHD patients. CONCLUSION: Based on our study results, sleep parameters and cognitive function were closely associated in ADHD patients; further research should be directed at clarifying this crucial link.
OBJECTIVE: Sleep problems are common among patients with attention-deficit hyperactivity disorder (ADHD), and are considered major causes of behavioral and cognitive dysfunction in ADHDpatients. In the present study, we investigated the relationship between sleep parameters and cognitive function in drug-naïve children with ADHD. METHODS: Twenty-eight patients were recruited to participate in the study, and a polysomnography was used to measure sleep parameters of the subjects. Cognitive measurements were collected, utilizing the Wechsler Intelligence Scale for Children-III (WISC-III), and the Matching Familiar Figure Test for Korean Children (MFFT-KC), while behavioral characteristics of the subjects were assessed using Conners' Global Index-Parent version (CGI-P). Descriptive statistics were calculated for demographic data, sleep parameters, and neurocognitive characteristics of ADHDpatients. Spearman's correlation analyses were performed to determine the association between sleep parameters and neurocognitive measures. Moreover, multiple regression analyses were used to identify the best predictors of cognitive function among the various sleep parameters. RESULTS: The regression analyses revealed several meaningful correlations, suggesting that slow wave sleep, stage 2 sleep, REM sleep, and limb movement index with arousals (LMAs) as predictors of cognitive function in ADHDpatients. CONCLUSION: Based on our study results, sleep parameters and cognitive function were closely associated in ADHDpatients; further research should be directed at clarifying this crucial link.
Authors: Phoebe K Yu; Jerilynn Radcliffe; H Gerry Taylor; Raouf S Amin; Cristina M Baldassari; Thomas Boswick; Ronald D Chervin; Lisa M Elden; Susan L Furth; Susan L Garetz; Alisha George; Stacey L Ishman; Erin M Kirkham; Christopher Liu; Ron B Mitchell; S Kamal Naqvi; Carol L Rosen; Kristie R Ross; Jay R Shah; Ignacio E Tapia; Lisa R Young; David A Zopf; Rui Wang; Susan Redline Journal: Sleep Date: 2022-02-12 Impact factor: 6.313