| Literature DB >> 26922432 |
Zhe Ma1, Binbin Niu1, Zhangyan Shi1, Junlin Li1, Jian Wang2, Fuchang Zhang1,2, Xiaocai Gao3,4,5, Kejin Zhang6.
Abstract
Previous studies have indicated that the cognitive impairment or deficit is associated with GABAergic signaling in central nervous system. Inspired by the finding that receptor GABRR2 modulates concentration of GABA and phasic inhibitory GABAergic transmission in brain. This study investigated to what extent a genetic variant (c.1423C>T, rs282129) of GABRR2 gene modulates individuals' general cognitive ability in 987 Chinese Han people. Results showed a significant influence of GABRR2 gene polymorphism on individuals' Raven's Standard Progressive Matrices (RSPM) performance (F = 3.58, P = .028 by ANOVA and χ 2 = 9.35, P = .009 by K-W test, respectively), even if non-genetic factors were partialed out (gender, major, types of birthplace, and socioeconomic index) (B = -.67, SE = .26, t = 2.63, P = .009). The finding provided a strong evidence, to our knowledge, for the view that genetic variant of GABRR2 gene may contribute to the difference of individuals' general cognitive ability, independently.Entities:
Keywords: Gamma-aminobutyric acid (GABA); General cognitive ability; Genetic variants; Raven’s Standard Progressive Matrices (RSPM)
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Year: 2016 PMID： 26922432 DOI： 10.1007/s10571-016-0347-2
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046