| Literature DB >> 2692241 |
Abstract
The advent of pulsed field gradient electrophoresis has proved remarkably useful for studying chromosomes of the genetically intractable malaria parasite Plasmodium falciparum. Advances include determination of the karyotype, a linkage map and restriction maps of individual chromosomes that enable the ordering of genes. The structural basis underlying a frequently occurring form of chromosome size polymorphism is now understood and other polymorphisms are providing tantalizing clues to the mechanisms underlying drug resistance.Entities:
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Year: 1989 PMID: 2692241 DOI: 10.1016/0168-9525(89)90139-x
Source DB: PubMed Journal: Trends Genet ISSN: 0168-9525 Impact factor: 11.639