Belen Núñez1, Jaume Sauleda2, Judith Garcia-Aymerich3, Aina Noguera4, Eduard Monsó5, Federico Gómez6, Esther Barreiro7, Alicia Marín5, Josep Maria Antó3, Alvar Agusti8. 1. Servei de Pneumologia, Hospital Universitari Son Espases, Palma de Mallorca, España; Instituto de Investigación Sanitaria de Palma (IdisPa), Palma de Mallorca, España; CIBER Enfermedades Respiratorias (CIBERES), España. 2. Servei de Pneumologia, Hospital Universitari Son Espases, Palma de Mallorca, España; Instituto de Investigación Sanitaria de Palma (IdisPa), Palma de Mallorca, España; CIBER Enfermedades Respiratorias (CIBERES), España. Electronic address: jaume.sauleda@ssib.es. 3. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, España; Departament de Ciències Experimentals i de la Salut (CEXS), Universitat Pompeu Fabra, Barcelona, España; CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, España. 4. Servei de Pneumologia, Hospital Universitari Son Espases, Palma de Mallorca, España; Instituto de Investigación Sanitaria de Palma (IdisPa), Palma de Mallorca, España; Servei d'Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, España. 5. CIBER Enfermedades Respiratorias (CIBERES), España; Hospital Parc Taulí, Sabadell, Barcelona, España. 6. CIBER Enfermedades Respiratorias (CIBERES), España; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España. 7. CIBER Enfermedades Respiratorias (CIBERES), España; Departament de Ciències Experimentals i de la Salut (CEXS), Universitat Pompeu Fabra, Barcelona, España; Grupo de Investigación en Mecanismos de Predisposición al Cáncer de Pulmón, IMIM (Hospital del Mar Medical Research Institute), Barcelona, España; Servei de Pneumologia, Hospital del Mar, Barcelona, España. 8. CIBER Enfermedades Respiratorias (CIBERES), España; Institut del Tòrax, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, España.
Abstract
INTRODUCTION: The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators from the lung to the circulation. OBJECTIVE: To evaluate the relationship between pulmonary and systemic inflammation in COPD quantifying several inflammatory markers in sputum and serum determined simultaneously. METHODOLOGY: Correlations between various inflammatory variables (TNF-α, IL6, IL8) in sputum and serum were evaluated in 133 patients from the PAC-COPD cohort study. A secondary objective was the evaluation of relationships between inflammatory variables and lung function. RESULTS: Inflammatory markers were clearly higher in sputum than in serum. No significant correlation was found (absolute value, r=0.03-0.24) between inflammatory markers in blood and in sputum. There were no significant associations identified between those markers and lung function variables, such as FEV1, DLCO and PaO2 neither. CONCLUSIONS: We found no correlation between pulmonary and systemic inflammation in patients with stable COPD, suggesting different pathogenic mechanisms.
INTRODUCTION: The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators from the lung to the circulation. OBJECTIVE: To evaluate the relationship between pulmonary and systemic inflammation in COPD quantifying several inflammatory markers in sputum and serum determined simultaneously. METHODOLOGY: Correlations between various inflammatory variables (TNF-α, IL6, IL8) in sputum and serum were evaluated in 133 patients from the PAC-COPD cohort study. A secondary objective was the evaluation of relationships between inflammatory variables and lung function. RESULTS: Inflammatory markers were clearly higher in sputum than in serum. No significant correlation was found (absolute value, r=0.03-0.24) between inflammatory markers in blood and in sputum. There were no significant associations identified between those markers and lung function variables, such as FEV1, DLCO and PaO2 neither. CONCLUSIONS: We found no correlation between pulmonary and systemic inflammation in patients with stable COPD, suggesting different pathogenic mechanisms.
Authors: Rosa Faner; Jarrett D Morrow; Sandra Casas-Recasens; Suzanne M Cloonan; Guillaume Noell; Alejandra López-Giraldo; Ruth Tal-Singer; Bruce E Miller; Edwin K Silverman; Alvar Agustí; Craig P Hersh Journal: Respir Res Date: 2019-01-08
Authors: J M Kiszałkiewicz; S Majewski; W J Piotrowski; P Górski; D Pastuszak-Lewandoska; M Migdalska-Sęk; E Brzeziańska-Lasota Journal: Sci Rep Date: 2021-11-23 Impact factor: 4.379
Authors: E Arellano-Orden; C Calero Acuña; V Sánchez-López; C López Ramírez; R Otero-Candelera; C Marín-Hinojosa; Jl López Campos Journal: Eur Clin Respir J Date: 2022-07-08
Authors: Rafael Golpe; Irene Martín-Robles; Pilar Sanjuán-López; Luis Pérez-de-Llano; Carlos González-Juanatey; José L López-Campos; Elena Arellano-Orden Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-09-01
Authors: Luis Pérez de Llano; Borja G Cosío; Amanda Iglesias; Natividad de Las Cuevas; Juan Jose Soler-Cataluña; Jose Luis Izquierdo; Jose Luis López-Campos; Carmen Calero; Vicente Plaza; Marc Miravitlles; Alfons Torrego; Eva Martinez-Moragon; Joan B Soriano; Antolin Lopez Viña; Irina Bobolea Journal: Int J Chron Obstruct Pulmon Dis Date: 2018-02-12